The diverse pleiotropic pharmacological effects of curcumin nanoformulations have turned it into an attractive natural compound in different health-related problems. A great body of evidence has shown the impact of curcumin and its nanoformulations on the differentiation of stem cells. The current review highlights cellular and molecular mechanisms connected with the osteogenic differentiation of mesenchymal stem cells (MSCs) in the scaffolds benefiting from the presence of nanocurcumin pointing toward the role of inhibitory or stimulant signal transduction pathways in detail. Moreover, the effects of different concentrations as well as the structural modifications of curcumin on the differentiation of MSCs have been addressed.

中文翻译：

---

通过含有姜黄素的纳米支架对间充质干细胞的成骨分化

姜黄素纳米制剂的多种多效药理作用使其成为解决不同健康相关问题的有吸引力的天然化合物。大量证据表明姜黄素及其纳米制剂对干细胞分化的影响。当前的综述强调了与支架中间充质干细胞 (MSC) 的成骨分化相关的细胞和分子机制，这些机制受益于纳米姜黄素的存在，并详细指出了抑制或刺激信号转导途径的作用。此外，不同浓度的姜黄素以及结构修饰对 MSCs 分化的影响已经得到解决。