Abstract

Background

In daily practice, C-reactive protein (CRP) may be used to predict recurrence and treatment response in patients with acute pericarditis; however, the predictive role of CRP might be insufficient for clinical prediction in some patients. In this study, we aimed to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and the composite endpoint of pericarditis recurrence and/or tamponade within 1 year in patients with acute pericarditis.

Methods

A total of 104 patients diagnosed with acute idiopathic pericarditis (mean age 42.8 ± 15.2 years, 55.8% male) were included in the study. Physical examination findings of these patients, electrocardiography, echocardiography, chest X-ray and laboratory findings were evaluated and analysed. During the 1-year follow-up, the composite of cardiac tamponade and/or pericarditis recurrence was investigated as the primary endpoint of the study.

Results

Compared to the group without the composite outcome, the group with the composite outcome had significantly higher rates of moderate and severe pericardial effusion (p < 0.01) and higher white blood cell (WBC) count (p:0.001), platelet count (p = 0.003), NLR (2.14 (1.49–3.02) vs 6.60 (5.50–8.68); p < 0.001) and high-sensitivity C-reactive protein (hs-CRP) (8.01 (5.1–24.5 vs 69.5 (40.8–128); p:0.001). Higher hs-CRP (p < 0.001), WBC (p:0.001), NLR (p < 0.001) and platelets (p:0.02) were associated with pericarditis recurrence. NLR and hs-CRP were independently associated with the composite endpoint (p < 0.001 and p < 0.001, respectively).

Conclusion

NLR and hs-CRP were found to be independent predictors for the composite endpoint of tamponade and/or recurrence in acute pericarditis patients during the 1-year follow-up. Similar to hs-CRP, NLR may also be used for risk assessment in patients with idiopathic pericarditis.

中文翻译：

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中性粒细胞与淋巴细胞的比率对预测急性心包炎结局的有用性

摘要

背景

在日常实践中，C 反应蛋白 (CRP) 可用于预测急性心包炎患者的复发和治疗反应；然而，CRP 的预测作用可能不足以对某些患者进行临床预测。在本研究中，我们旨在调查急性心包炎患者中中性粒细胞与淋巴细胞比率 (NLR) 与 1 年内心包炎复发和/或心包填塞复合终点之间的关系。

方法

共有 104 名诊断为急性特发性心包炎的患者（平均年龄 42.8 ± 15.2 岁，55.8% 男性）被纳入研究。对这些患者的体格检查结果、心电图、超声心动图、胸部 X 光片和实验室检查结果进行了评估和分析。在 1 年的随访期间，将心脏压塞和/或心包炎复发的复合材料作为研究的主要终点进行了调查。

结果

与无复合结局组相比，有复合结局组的中重度心包积液发生率显着升高（p  < 0.01），白细胞（WBC）计数（p：0.001）、血小板计数（p  = 0.003)、NLR (2.14 (1.49–3.02) vs 6.60 (5.50–8.68)；p  < 0.001) 和高敏 C 反应蛋白 (hs-CRP) (8.01 (5.1–24.5 vs 69.5 (40.8–128))； p:0.001)。较高的 hs-CRP ( p  < 0.001)、WBC (p:0.001)、NLR ( p  < 0.001) 和血小板 (p:0.02) 与心包炎复发相关。NLR 和 hs-CRP 与心包炎复发独立相关。复合终点（分别为p  < 0.001 和p  < 0.001）。

结论

NLR 和 hs-CRP 被发现是 1 年随访期间急性心包炎患者心包填塞和/或复发复合终点的独立预测因子。与 hs-CRP 类似，NLR 也可用于特发性心包炎患者的风险评估。