Magnetic 45S5 bioactive glass (BG) based scaffolds covered with iron-loaded hydroxyapatite (Fe-HA-BG) nanoparticles were obtained and its cytotoxicity investigated. Fe-HA nanoparticles were synthesized by a wet chemical method involving the simultaneous addition of Fe²⁺/Fe³⁺ ions. BG based scaffolds were prepared by the foam replica procedure and covered with Fe-HA by dip-coating. Fe-HA-BG magnetic saturation values of 0.049 emu g⁻¹ and a very low remanent magnetization of 0.01 emu g⁻¹ were observed. The mineralization assay in simulated body fluid following Kokubo’s protocol indicated that Fe-HA-BG scaffolds exhibited improved hydroxyapatite formation in comparison to uncoated scaffolds at shorter immersion times. The biocompatibility of the material in vitro was assessed using human osteoblast-like MG-63 cell cultures and mouse bone marrow-derived stroma cell line ST-2. Overall, the results herein discussed suggest that magnetic Fe-HA coatings seem to enhance the biological performance of 45S5 BG based scaffolds. Thus, this magnetic Fe-HA coated scaffold is an interesting system for bone tissue engineering applications and warrant further investigation.

获得了覆盖有铁负载羟基磷灰石 (Fe-HA-BG) 纳米颗粒的磁性 45S5 生物活性玻璃 (BG) 支架，并研究了其细胞毒性。Fe-HA纳米粒子通过湿化学方法合成，包括同时添加Fe ²⁺ /Fe ³⁺离子。通过泡沫复制程序制备基于 BG 的支架，并通过浸涂用 Fe-HA 覆盖。Fe-HA-BG 磁饱和值为 0.049 emu g ^{-1和 0.01 emu g -1}的极低剩磁被观察到。根据 Kokubo 的方案在模拟体液中进行的矿化分析表明，与未涂覆的支架相比，Fe-HA-BG 支架在较短的浸泡时间下表现出改善的羟基磷灰石形成。使用人成骨细胞样 MG-63 细胞培养物和小鼠骨髓来源的基质细胞系 ST-2 评估了该材料的体外生物相容性。总体而言，本文讨论的结果表明磁性 Fe-HA 涂层似乎增强了 45S5 BG 基支架的生物学性能。因此，这种磁性 Fe-HA 涂层支架是用于骨组织工程应用的有趣系统，值得进一步研究。