The ARP2/3 complex promotes branched actin networks, but the importance of specific subunit isoforms is unclear. In this issue, Galloni, Carra, et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202102043) show that MICAL2 mediates methionine oxidation of ARP3B, thus destabilizing ARP2/3 complexes and leading to disassembly of branched actin filaments.

中文翻译：

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MICAL2 微调 Arp2/3 的肌动蛋白分支


ARP2/3 复合物促进分支肌动蛋白网络，但特定亚基亚型的重要性尚不清楚。在本期中，加洛尼、卡拉等人。 (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202102043) 表明 MICAL2 介导 ARP3B 的甲硫氨酸氧化，从而破坏 ARP2/3 复合物的稳定性并导致分支肌动蛋白丝分解。