Radio frequency ablation (RFA) is a proven technique for eliminating cancerous or dysfunctional tissues in the body. However, the delivery of RFA electrodes to deep tissues causes damage to overlying healthy tissues, while a minimally invasive RFA technique would limit damage to targeted tissues alone. In this manuscript, we propose a wireless RFA technique relying on the absorption of radio frequencies (RFs) by gold nanowires in vivo and the deep penetration of RF into biological tissues. Upon optimizing the dimensions of the gold nanowires and the frequency of the applied RF for breast cancer and myocardium tissues, we find that heating rates in excess of 2000 K/s can be achieved with high spatial resolution in vivo, enabling short heating durations for ablation and minimizing heat diffusion to surrounding tissues. The results suggest that gold nanowires can act as “radiothermal” agents to concentrate heating within targeted tissues, negating the need to implant bulky electrodes for tissue ablation.

中文翻译：

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利用纳米线天线进行无线射频消融的可行性


射频消融 (RFA) 是一种经过验证的消除体内癌变或功能失调组织的技术。然而，将 RFA 电极输送到深层组织会对上层健康组织造成损害，而微创 RFA 技术将仅限制对目标组织的损害。在这篇手稿中，我们提出了一种无线 RFA 技术，该技术依赖于体内金纳米线对射频 (RF) 的吸收以及 RF 深入生物组织的渗透。通过优化金纳米线的尺寸以及对乳腺癌和心肌组织应用射频的频率，我们发现在体内可以以高空间分辨率实现超过 2000 K/s 的加热速率，从而实现较短的消融加热持续时间并最大限度地减少向周围组织的热扩散。结果表明，金纳米线可以充当“放射热”剂，将热量集中在目标组织内，从而无需植入笨重的电极来进行组织消融。