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Self-help plus for refugees and asylum seekers; study protocol for a series of individual participant data meta-analyses.
European journal of psychotraumatology Pub Date : 2021-07-05 , DOI: 10.1080/20008198.2021.1930690
Eirini Karyotaki 1, 2, 3 , Marit Sijbrandij 1, 2 , Marianna Purgato 4 , Ceren Acarturk 5 , Daniel Lakin 6 , Della Bailey 7 , Emily Peckham 7 , Ersin Uygun 8 , Federico Tedeschi 4 , Johannes Wancata 9 , Jura Augustinavicius 6 , Ken Carswell 10 , Maritta Välimäki 11 , Mark van Ommeren 10 , Markus Koesters 12 , Mariana Popa 13 , Marx Ronald Leku 14 , Minna Anttila 11 , Rachel Churchill 15 , Ross White 13 , Sarah Al-Hashimi 9 , Tella Lantta 11 , Teresa Au 10 , Thomas Klein 12 , Wietse A Tol 6 , Pim Cuijpers 1, 2 , Corrado Barbui 4
Affiliation  

Background Refugees and asylum seekers face various stressors due to displacement and are especially vulnerable to common mental disorders. To effectively manage psychological distress in this population, innovative interventions are required. The World Health Organization (WHO) Self-Help Plus (SH+) intervention has shown promising outcomes in reducing symptoms of common mental disorders among refugees and asylum seekers. However, individual participant differences in response to SH+ remain largely unknown. The Individual Participant Data (IPD) meta-analysis synthesizes raw datasets of trials to provide cutting-edge evidence of outcomes that cannot be examined by conventional meta-analytic approaches. Objectives This protocol outlines the methods of a series of IPD meta-analyses aimed at examining the effects and potential moderators of SH+ in (a) reducing depressive symptoms at post-intervention and (b) preventing the six-month cumulative incidence of mental disorders in refugees and asylum seekers. Method RCTs on SH+ have been identified through WHO and all authors have agreed to share the datasets of the trials. The primary outcomes of the IPD meta-analyses are (a) reduction in depressive symptoms at post-intervention, and (b) prevention of six-month cumulative incidence of mental disorders. Secondary outcomes include post-traumatic stress disorder symptoms, well-being, functioning, quality of life, and twelve-month cumulative incidence of mental disorders. One-stage IPD meta-analyses will be performed using mixed-effects linear/logistic regression. Missing data will be handled by multiple imputation. Conclusions These results will enrich current knowledge about the response to SH+ and will facilitate its targeted dissemination. The results of these IPD meta-analyses will be published in peer-reviewed journals.

中文翻译:

难民和寻求庇护者的自助服务;一系列个体参与者数据荟萃分析的研究方案。

背景 难民和寻求庇护者因流离失所而面临各种压力,尤其容易患上常见的精神障碍。为了有效地管理这一人群的心理困扰,需要创新的干预措施。世界卫生组织 (WHO) 的 Self-Help Plus (SH+) 干预措施在减少难民和寻求庇护者的常见精神障碍症状方面显示出可喜的成果。然而,个体参与者对 SH+ 的反应差异在很大程度上仍然未知。个体参与者数据 (IPD) 元分析综合了试验的原始数据集,以提供传统元分析方法无法检查的结果的前沿证据。目标 本协议概述了一系列 IPD 荟萃分析的方法,旨在检查 SH+ 在 (a) 减少干预后抑郁症状和 (b) 预防精神障碍的六个月累积发病率方面的影响和潜在调节剂难民和寻求庇护者。方法 SH+ 的 RCT 已通过 WHO 确定,所有作者都同意共享试验的数据集。IPD 荟萃分析的主要结果是 (a) 干预后抑郁症状减少,以及 (b) 预防精神障碍的六个月累积发病率。次要结果包括创伤后应激障碍症状、幸福感、功能、生活质量和精神障碍的 12 个月累积发病率。将使用混合效应线性/逻辑回归进行一阶段 IPD 荟萃分析。缺失数据将通过多重插补处理。结论 这些结果将丰富当前关于 SH+ 反应的知识,并将促进其有针对性的传播。这些 IPD 荟萃分析的结果将发表在同行评审的期刊上。
更新日期:2021-07-05
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