Clinicians commonly encounter middle-aged and older men who present with functional hypogonadism, that is, with clinical features compatible with androgen deficiency and lowered serum testosterone, but without evidence of organic hypothalamic-pituitary-testicular axis pathology. Whether, and when, testosterone therapy should be offered to such men remains uncertain and controversial, in part due to the lack of definitive evidence regarding long-term patient-important health outcomes with testosterone treatment. In this debate, we address this controversy and provide two opposing points of view on the role of testosterone treatment in older men with functional hypogonadism.

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中老年男性功能性性腺功能减退症：是否接受睾酮治疗？

临床医生通常会遇到出现功能性性腺功能减退症的中老年男性，即临床特征与雄激素缺乏和血清睾酮降低相符，但没有下丘脑-垂体-睾丸轴器质性病变的证据。是否以及何时应向这些男性提供睾酮治疗仍然不确定和有争议，部分原因是缺乏关于睾酮治疗对患者的长期重要健康结果的确切证据。在这场辩论中，我们解决了这一争议，并就睾酮治疗对患有功能性性腺功能减退症的老年男性的作用提出了两种相反的观点。