ABSTRACT

Aim

Epilepsy is one of the most common neurological diseases. Dexketoprofen (DEX) is a nonselective nonsteroidal anti-inflammatory drug that is used as an analgesic. The present study aimed to assess the efficiency of DEX on WAG/Rij rats by electrophysiologically and behaviorally.

Material and Methods

Twenty-eight male WAG/Rij rats were used. The effects of acute treatment with DEX (5, 25, and 50 mg/kg, i.p) on absence-like seizures, and related psychiatric comorbidity were assessed. The ECoG recording was taken for 180 min before and after drug injection. After drug injection and EcoG recording, anxiety-depression-like behavior was tested with the open field test for 5 min.

Results

The 5 mg/kg DEX significantly reduced the number and duration of SWDs percentage (p < 0.05) between 120 and 180 min, but 25 and 50 mg/kg DEX significantly increased the number and duration of SWDs percentage between 0 and 30 min (p < 0.05), and after 30 min the increase stopped (p > 0.05). And also, the 5 mg/kg DEX decreased the number and duration of SWDs percentage (p < 0.05) for 180 min (p < 0.05), but 25 and 50 mg/kg DEX administration did not alter (p > 0.05). The 5, 25, and 50 mg/kg doses of DEX significantly increased the duration of grooming (p < 0.05) but did not change the number of squares crossed (p > 0.05).

Conclusion

Low dose DEX reduced absence-like seizures, but care should be taken when using high doses in absence epilepsy. Also, it may be beneficial for painful diseases accompanied by anxiety-depression.

中文翻译：

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右酮洛芬氨丁三醇对失神癫痫WAG/Rij大鼠的影响（右酮洛芬失神癫痫）

摘要

目标

癫痫是最常见的神经系统疾病之一。右酮洛芬 (DEX) 是一种非选择性非甾体抗炎药，用作镇痛剂。本研究旨在通过电生理学和行为学评估 DEX 对 WAG/Rij 大鼠的效率。

材料与方法

使用了 28 只雄性 WAG/Rij 大鼠。评估了用 DEX（5、25 和 50 mg/kg，ip）急性治疗对失神样癫痫发作和相关精神疾病的影响。在药物注射前后进行 180 分钟的心电图记录。在药物注射和EcoG记录后，用旷场测试5分钟测试焦虑抑郁样行为。

结果

5 mg/kg DEX 显着降低了 120 至 180 分钟之间 SWD 百分比的数量和持续时间（p < 0.05），但 25 和 50 mg/kg DEX 显着增加了 0 至 30 分钟之间 SWD 百分比的数量和持续时间（p < 0.05)，30 分钟后停止增加 (p > 0.05)。此外，5 mg/kg DEX 减少了 SWDs 百分比的数量和持续时间（p < 0.05），持续 180 分钟（p < 0.05），但 25 和 50 mg/kg DEX 给药没有改变（p > 0.05）。5、25 和 50 mg/kg 剂量的 DEX 显着增加了梳理的持续时间 (p < 0.05)，但没有改变交叉的方块数 (p > 0.05)。

结论

低剂量 DEX 可减少失神样癫痫发作，但在失神癫痫中使用高剂量时应小心。此外，它可能对伴有焦虑抑郁的疼痛疾病有益。