Experimental Psychopathology (EPP) and the Research Domain Criteria (RDoC) are research approaches that have developed in parallel, providing inter-related yet different scientific frameworks to investigate psychopathology at the intersection of fundamental and applied research. Here we address the overlap and differences between RDoC and EPP, and the challenges that both approaches face. Although overlap between EPP and RDoC can be clearly observed, each approach has its own unique strengths and weaknesses. These aspects will be illustrated by examples with respect to fear conditioning, an experimental procedure that has played a central role in both EPP and RDoC. We see much potential in boosting psychopathology research by combining the strengths of these two approaches.

实验精神病理学 (EPP) 和研究领域标准 (RDoC) 是并行发展的研究方法，提供相互关联但不同的科学框架，以在基础研究和应用研究的交叉点研究精神病理学。在这里，我们解决了 RDoC 和 EPP 之间的重叠和差异，以及两种方法面临的挑战。尽管可以清楚地观察到 EPP 和 RDoC 之间的重叠，但每种方法都有其独特的优势和劣势。这些方面将通过有关恐惧条件反射的示例进行说明，这是一种在 EPP 和 RDoC 中都发挥核心作用的实验程序。通过结合这两种方法的优势，我们看到了促进精神病理学研究的巨大潜力。