This work aimed to theoretically predict the sono-recovery yield of value-added compounds in various neoteric solvents through considering solubility difference and acoustic-cavitation variability. Preferentially, the solvent-solute compatibility was calculated by Hansen solubility parameters (HSPs), but unexpectedly the results showed that the HSPs prediction was not preferably consistent with the tendency of extraction yield. Subsequently, calculated correlations between maximum bubble radius (MBR) and solvent properties showed the following hierarchies: viscosity (−0.86**) > density (−0.83**) > surface tension (−0.64**), and MBR can be considered as a mirror of solvent properties to reflect the flavonoids yield (r = 0.75**) but that was inapplicable to phenolic acids (r = 0.33). Evidentially, micromorphological observation exhibited that significant modification of epidermis had an intense disposition to occur in the solvents with greater MBR such as methanol, water and ethyl acetate. No significant sonochemiluminescence (SCL) signal was captured including aqueous malic acid/choline chloride (ChCl), lactic acid/ChCl, sucrose/ChCl, methanol, ethyl lactate, and glycerol, but the addition of ChCl into alcohols can enhance the production of free radicals. The generation of free radicals was independent of MBR and their impacts on final compounds presented pluralist and limited effects. In addition, how to more accurately quantify the effects of free radicals on the final compounds is still a poser. Overall, This work constructed a bridge between theoretical calculation and laboratory data and demonstrated the fundamentality of maximum bubble radius in the biorefinery of value-added compounds.

这项工作旨在通过考虑溶解度差异和声空化变异性，从理论上预测各种新溶剂中增值化合物的声回收率。优选地，溶剂-溶质相容性是通过汉森溶解度参数（HSPs）计算的，但出乎意料的是，结果表明HSPs的预测与提取率的趋势不一致。随后，最大气泡半径 (MBR) 和溶剂性质之间的计算相关性显示出以下层次结构：粘度 (-0.86**) > 密度 (-0.83**) > 表面张力 (-0.64**)，MBR 可以被认为是反映类黄酮产量 (r = 0.75**) 的溶剂特性镜子，但这不适用于酚酸 (r = 0.33)。显然，微观形貌观察表明，在甲醇、水和乙酸乙酯等MBR较大的溶剂中，表皮的显着改变具有强烈的倾向。未捕获到显着的声化学发光 (SCL) 信号，包括含水苹果酸/氯化胆碱 (ChCl)、乳酸/ChCl、蔗糖/ChCl、甲醇、乳酸乙酯和甘油，但将 ChCl 添加到醇中可以提高游离自由基。自由基的产生与 MBR 无关，它们对最终化合物的影响呈现出多元化和有限的影响。此外，如何更准确地量化自由基对最终化合物的影响仍然是一个摆设。全面的，