Background: Ovarian cancer is one of the leading causes of death worldwide. Polymers have low cytotoxicity and high functionalizability and are hence used for drug delivery systems, tissue engineering, and polymer therapeutics. In drug delivery systems, polymer-drug conjugates have shown considerable promise, especially in anticancer chemotherapy.

Objective: Anticancer Drug Delivery Systems (DDS) deliver drugs to the tumor site leading to reduced exposure of the drugs to healthy cells and hence reduced side effects. Efforts have been made in the past to develop effective DDS using stimuli-responsive polymers like thermosensitive and pH-sensitive polymers.

Conclusion: Elastin-like Polypeptides (ELP), one of the thermoresponsive polymers, have been identified as drug carriers in anticancer therapy. ELP-drug conjugates have the potential and can be used effectively in combination with hyperthermia for targeting drugs to solid tumors. This review reports on the use of ELPs in cancer therapy, its biomedical applications, and recent developments to target drugs to ovarian solid tumors.

背景：卵巢癌是全球主要的死亡原因之一。聚合物具有低细胞毒性和高功能化能力，因此可用于药物递送系统、组织工程和聚合物治疗。在药物递送系统中，聚合物-药物偶联物已显示出相当大的前景，尤其是在抗癌化疗中。

目的：抗癌药物输送系统 (DDS) 将药物输送到肿瘤部位，从而减少药物与健康细胞的接触，从而减少副作用。过去已经努力使用刺激响应聚合物（如热敏和 pH 敏感聚合物）开发有效的 DDS。

结论：弹性蛋白样多肽（ELP）是一种热响应性聚合物，已被确定为抗癌治疗的药物载体。ELP-药物偶联物具有潜力并且可以有效地与热疗联合使用以将药物靶向实体瘤。本综述报告了 ELP 在癌症治疗中的应用、其生物医学应用以及针对卵巢实体瘤的靶向药物的最新进展。