Transcription factor (TF)-induced reprogramming of somatic cells across lineages and to induced pluripotent stem cells (iPSCs) has revealed a remarkable plasticity of differentiated cells and presents great opportunities for generating clinically relevant cell types for disease modeling and regenerative medicine. The understanding of iPSC reprogramming provides insights into the mechanisms that safeguard somatic cell identity, drive epigenetic reprogramming, and underlie cell fate specification in vivo. The combinatorial action of TFs has emerged as the key mechanism for the direct and indirect effects of reprogramming factors that induce the remodelling of the enhancer landscape. The interplay of TFs in iPSC reprogramming also yields trophectoderm- and extraembryonic endoderm-like cell populations, uncovering an intriguing plasticity of cell states and opening new avenues for exploring cell fate decisions during early embryogenesis.

中文翻译：

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iPSC 重编程中的转录因子代码。

转录因子 (TF) 诱导的跨谱系体细胞重编程和诱导多能干细胞 (iPSC) 揭示了分化细胞的显着可塑性，并为生成用于疾病建模和再生医学的临床相关细胞类型提供了巨大机会。对 iPSC 重编程的理解提供了对保护体细胞身份、驱动表观遗传重编程和体内细胞命运规范基础的机制的见解。TF 的组合作用已成为重编程因子直接和间接影响增强子景观重塑的关键机制。iPSC 重编程中 TF 的相互作用也会产生滋养外胚层和胚外内胚层样细胞群，