Abstract

Objectives

To evaluate acute changes in serum brain-derived neurotrophic factor (BDNF) concentration following combined endurance exercise and heat stress through head-out water immersion (HOI).

Setting

Observational study with crossover design.

Methods

Ten healthy young male participants performed HOI at 40 °C (40 °C HOI) or continuous cycling at 60% of maximal oxygen uptake while immersed in 40 °C (40 °C HOI-ex) or 23 °C water (23 °C HOI-ex) for 15 min. Serum BDNF, cortisol and lactate concentrations, and core temperature (T_core) were measured pre, immediately post, and 15 and 30 min post-immersion.

Results

BDNF concentration increased immediately and 15 min after 40 °C HOI-ex, but not after 40 °C or 23 °C HOI-ex. No changes in T_core concentration were observed during 23 °C HOI-ex (Pre; 37.3 °C ± 0.3 °C, Post; 37.8 °C ± 0.2 °C, Post 15; 37.4 °C ± 0.3 °C, Post 30; 37.2 °C ± 0.2 °C). T_core increased significantly post, post 15, and post 30 min of 40 °C HOI (Pre; 37.1 °C ± 0.4 °C, Post; 38.8 °C ± 0.5 °C, Post 15; 37.9 °C ± 0.4 °C, Post 30; 37.9 °C ± 0.2 °C) and 40 °C HOI-ex (Pre; 37.2 °C ± 0.2 °C, Post; 40.2 °C ± 0.7 °C, Post 15; 38.9 °C ± 0.5 °C, Post 30; 38.3 °C ± 0.5 °C). T_core was higher in 40 °C HOI-ex compared with 40 °C HOI and 23 °C HOI-ex immediately post and post 15 min. Plasma lactate and cortisol were significantly higher in 40 °C HOI-ex compared with 40 °C HOI and 23 °C HOI-ex after immersion (p = 0.001).

Conclusion

While 15 min HOI alone or thermoneutral exercise do not increase BDNF concentration, both combined may form a time-efficient strategy to acutely elevate BDNF.

中文翻译：

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耐力运动联合高温冲水浸泡对健康青年男性血清脑源性神经营养因子浓度的影响

摘要

目标

评估通过头出水浸 (HOI) 进行耐力运动和热应激联合后血清脑源性神经营养因子 (BDNF) 浓度的急性变化。

环境

具有交叉设计的观察性研究。

方法

10 名健康的年轻男性参与者在 40 °C (40 °C HOI) 下进行 HOI 或以最大摄氧量的 60% 持续循环，同时浸入 40 °C (40 °C HOI-ex) 或 23 °C 水中 (23 °C) HOI-ex) 15 分钟。血清 BDNF、皮质醇和乳酸浓度以及核心温度 (T _core ) 在浸泡前、浸泡后立即和 15 分钟和 30 分钟后测量。

结果

BDNF 浓度在 40 °C HOI-ex 后立即增加和 15 分钟增加，但在 40 °C 或 23 °C HOI-ex 后不会增加。在 23 °C HOI-ex 期间未观察到T_核心浓度的变化（前；37.3 °C ± 0.3 °C，后；37.8 °C ± 0.2 °C，后 15；37.4 °C ± 0.3 °C，后 30； 37.2 °C ± 0.2 °C）。T_核心在 40 °C HOI 后、15 分钟和 30 分钟后显着增加（前；37.1 °C ± 0.4 °C，后；38.8 °C ± 0.5 °C，后 15；37.9 °C ± 0.4 °C，后 30；37.9 °C ± 0.2 °C) 和 40 °C HOI-ex（前；37.2 °C ± 0.2 °C，后；40.2 °C ± 0.7 °C，后 15；38.9 °C ± 0.5 °C，后 30；38.3 °C ± 0.5 °C）。T_核与 40 °C HOI 和 23 °C HOI-ex 相比，在 40 °C HOI-ex 中立即和 15 分钟后更高。与浸泡后的 40°C HOI 和 23°C HOI-ex 相比，40°C HOI-ex 中的血浆乳酸和皮质醇显着更高 ( p  = 0.001)。

结论

虽然单独的 15 分钟 HOI 或热中性运动不会增加 BDNF 的浓度，但两者结合可能形成一种节省时间的策略来急剧提升 BDNF。