Abstract

Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) caused by the inhalation of antigens. Antigen-specific IgG antibodies (sIgG) are used as biomarkers of exposure when diagnosing HP, but little is known about the longitudinal relation between antibody levels and risk of HP or other ILD. In a follow-up design, we explored the relationship between sIgG antibodies against Aspergillus fumigatus and the diagnosis of HP in 647 subjects suspected of HP. We showed that IgG levels above the reference value resulted in a hazard ratio of 9.5 for subsequent HP. Our findings support a relationship between high levels of sIgG against A. fumigatus and risk of HP.

摘要

过敏性肺炎（HP）是一种由吸入抗原引起的间质性肺病（ILD）。在诊断 HP 时，抗原特异性 IgG 抗体 (sIgG) 被用作暴露的生物标志物，但对于抗体水平与 HP 或其他 ILD 风险之间的纵向关系知之甚少。在后续设计中，我们探讨了647 名疑似 HP 受试者的烟曲霉sIgG 抗体与 HP 诊断之间的关系。我们表明，高于参考值的 IgG 水平导致后续 HP 的风险比为 9.5。我们的研究结果支持高水平的烟曲霉 sIgG与 HP 风险之​​间的关系。