T cells undergo activation, maturation, and differentiation in which they can substantially transform and restructure. This includes metabolic adaptations which have been well recognized to be specific for T cell subsets. T cell subset-specific metabolism is thought to reflect different bioenergetic requirements as well as adaptations to environmental conditions in which the T cells operate. The metabolic changes that occur in T cells are orchestrated by signaling cascades that lead to rapid post-translational changes and through transcription factors which facilitate more long-term adaptations. In addition, metabolites produced within T cells or taken up from the environment can influence gene expression by altering chromatin accessibility or the effectiveness of transcription factors through post-translational modifications, and thus act as transcription regulators in their own right.

中文翻译：

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T细胞代谢的转录调控和T细胞基因表达的代谢控制。

T 细胞经历活化、成熟和分化，在这些过程中它们可以显着转化和重组。这包括公认的对 T 细胞亚群特异的代谢适应。T 细胞亚群特异性代谢被认为反映了不同的生物能量需求以及对 T 细胞运行的环境条件的适应。T 细胞中发生的代谢变化是通过导致快速翻译后变化的信号级联和通过促进更长期适应的转录因子来协调的。此外，在 T 细胞内产生或从环境中吸收的代谢物可以通过翻译后修饰改变染色质的可及性或转录因子的有效性来影响基因表达，