Abstract

A promising area of modern coordination and supramolecular chemistry is the synthesis of biologically active compounds of germanium and creation of effective drugs, biomaterials, and enzyme modulators based thereon. The present review deals with biologically active compounds of germanium(IV) and contributes to the solution of problems of synthesis, physicochemical analysis, and prediction of biological activity of germanium complexes with a wide spectrum of action. Some features of coordination and chemical properties of organic acids and amino acids in the complexation with germanium dioxide and chloride have been demonstrated. The literature data on the complexation conditions, crystal and supramolecular structures of germanium(IV) complexes, geometry of germanium coordination polyhedra, types of hydrogen bonds, topology of coordination shells, and pharmacological and biological properties of a number of compounds are considered.

中文翻译：

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锗的生物活性配位化合物。合成及理化性质

摘要

现代配位和超分子化学的一个有前景的领域是锗的生物活性化合物的合成以及基于此的有效药物、生物材料和酶调节剂的创造。本综述涉及锗 (IV) 的生物活性化合物，有助于解决具有广泛作用的锗配合物的合成、理化分析和生物活性预测问题。已经证明了有机酸和氨基酸在与二氧化锗和氯化物络合中的配位和化学性质的一些特征。关于配合条件、锗 (IV) 配合物的晶体和超分子结构、锗配位多面体几何形状、氢键类型、配位壳拓扑结构的文献数据，