Abstract

2-Substituted benzimidazole derivatives were synthesized by condensation of o-phenylenediamine with the corresponding substituted benzaldehydes and were alkylated at the nitrogen atom using C₃–C₁₀ alkyl bromides in the presence of tetrabutylammonium hydrogen sulfate as a phase-transfer catalyst and 30% aqueous potassium hydroxide as a base. The synthesized derivatives were characterized by ¹H and ¹³C NMR and IR spectroscopy and screened for their nematicidal activity against the root-knot nematode Meloidogyne incognita by egg hatching and mortality tests. All compounds exhibited significant nematicidal potential as compared to control. The maximum egg hatching inhibition potential and maximum mortality potential were exhibited by 2-(2-nitrophenyl)-1H-benzimidazole.

中文翻译：

---

2-取代苯并咪唑衍生物的 N-烷基化及其作为抗胺剂的评价

摘要

2-取代苯并咪唑衍生物是通过邻苯二胺与相应取代苯甲醛缩合合成的，并在四丁基硫酸氢铵作为相转移催化剂和 30% 水溶液存在下使用 C ₃ -C ₁₀烷基溴在氮原子处烷基化氢氧化钾为碱。合成的衍生物通过¹ H 和¹³ C NMR 和 IR 光谱表征，并筛选了它们对根结线虫南方根结线虫的杀线虫活性通过卵孵化和死亡率测试。与对照相比，所有化合物都表现出显着的杀线虫潜力。2-(2-硝基苯基)-1 H-苯并咪唑表现出最大的卵孵化抑制潜力和最大的死亡潜力。