Abstract

Polyurethane hydrogels containing polyethylene glycol as a linear fragment and incomplete β-cyclodextrin nitrate as a cross-linking agent were synthesized. The polyols were cross-linked with 1,6-hexamethylene diisocyanate. The hydrogel swelling ratio was studied as a function of the content of partially nitrated β-cyclodextrin in the hydrogel, molecular mass of polyethylene glycol, and degree of substitution of hydroxy groups by nitrate groups in incomplete β-cyclodextrin nitrates. As the cyclodextrin nitrate content is increased from 13 to 44 wt %, the swelling ratio relative to the dry substance weight decreases from 9.5 to 2.3. An increase in the molecular mass of polyethylene glycol from 0.4 to 20 kDa leads to an increase in the swelling ratio from 1.6 to 5.1 for weakly cross-linked polyurethane hydrogels and from 1.2 to 2.8 for the thickly cross-linked hydrogels. The ability of the synthesized compounds to absorb Methylene Blue, Methyl Orange, and phenol was studied. Polyurethane hydrogels do not absorb Methylene Blue. The absorption of Methyl Orange and phenol depends both on the content of incomplete β-cyclodextrin nitrate and on the hydrogel swelling ratio. The synthesized polyurethane hydrogels are biologically compatible.

中文翻译：

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基于部分β-环糊精硝酸盐和聚乙二醇的聚氨酯水凝胶的吸收性能

摘要

合成了含有聚乙二醇作为线性片段和不完全β-环糊精硝酸盐作为交联剂的聚氨酯水凝胶。多元醇与 1,6-六亚甲基二异氰酸酯交联。研究了水凝胶溶胀率与水凝胶中部分硝化 β-环糊精的含量、聚乙二醇的分子量和不完全 β-环糊精硝酸盐中羟基被硝酸基团取代的程度的函数。随着硝酸环糊精含量从 13 重量％增加到 44 重量％，相对于干物质重量的溶胀比从 9.5 减少到 2.3。聚乙二醇的分子量从 0.4 kDa 增加到 20 kDa，导致弱交联聚氨酯水凝胶的溶胀比从 1.6 增加到 5.1，从 1.2 增加到 2。8 为厚交联的水凝胶。研究了合成化合物吸收亚甲蓝、甲基橙和苯酚的能力。聚氨酯水凝胶不吸收亚甲蓝。甲基橙和苯酚的吸收取决于不完全β-环糊精硝酸盐的含量和水凝胶溶胀率。合成的聚氨酯水凝胶具有生物相容性。