The diverse library of biologically active organic compounds is composed majorly of heterocyclic compounds. Nature provides a variety of pharmacologically active compounds consisting of N-heterocycle motif, such as Noscapine (anti-cancer), Morphine (analgesic), Chelerythrine (antibacterial), etc. which are the elementary structural units of marketed drugs in the present era. One such “N-heterocyclic” promising building block which has gained the attention of chemists is Pyrazinoindoles and the inflating interest in this moiety is a result of the three-fused heterocyclic ring structure subsuming an indolic nucleus in it. Fused-polycyclic structural core is necessary to synthesize potential multi-functional drugs, which is evident from indole (an example of fused five and sixmembered ring structure) being an exemplary and established privileged template in medicinal chemistry. In the literature, Pyrazino-fused indoles have been found documented regarding their biological activities and therapeutic uses, particularly as antifungal, antibacterial, serotonergic receptor inhibitor, central nervous system depressants, anticonvulsants, antihistaminic, protein kinase C inhibitors, anti-depressants and so on. Although various synthesis strategies are available in the literature, yet the medical relevance of the Pyrazinoindoles demands the development of versatile and simple novel methodologies. This review features a comprehensive overview of the recent developments in synthetic approaches and therapeutic applications of Pyrazinoindoles based scaffolds.

生物活性有机化合物的多样化库主要由杂环化合物组成。自然界提供了多种由N-杂环基序组成的药理活性化合物，如诺斯卡品（抗癌）、吗啡（镇痛）、白屈菜碱（抗菌）等，是当今市售药物的基本结构单元。一个这样的“N-杂环”有前途的结构单元已经引起了化学家的注意，它是吡嗪并吲哚，对这个部分的兴趣膨胀是其中包含一个吲哚核的三稠杂环结构的结果。融合多环结构核心是合成潜在多功能药物所必需的，这从吲哚（稠合五元和六元环结构的一个例子）是药物化学中一个典型的和建立的特权模板中可以明显看出。在文献中，已发现吡嗪并融合吲哚的生物活性和治疗用途，特别是作为抗真菌、抗菌、5-羟色胺能受体抑制剂、中枢神经系统抑制剂、抗惊厥药、抗组胺药、蛋白激酶 C 抑制剂、抗抑郁药等。 . 尽管文献中提供了各种合成策略，但 Pyrazinoindoles 的医学相关性需要开发通用且简单的新方法。本综述全面概述了基于吡嗪并吲哚的支架的合成方法和治疗应用的最新进展。特别是作为抗真菌、抗菌、5-羟色胺能受体抑制剂、中枢神经系统抑制剂、抗惊厥药、抗组胺药、蛋白激酶C抑制剂、抗抑郁药等。尽管文献中提供了各种合成策略，但 Pyrazinoindoles 的医学相关性需要开发通用且简单的新方法。本综述全面概述了基于吡嗪并吲哚的支架的合成方法和治疗应用的最新进展。特别是作为抗真菌、抗菌、5-羟色胺能受体抑制剂、中枢神经系统抑制剂、抗惊厥药、抗组胺药、蛋白激酶C抑制剂、抗抑郁药等。尽管文献中提供了各种合成策略，但 Pyrazinoindoles 的医学相关性需要开发通用且简单的新方法。本综述全面概述了基于吡嗪并吲哚的支架的合成方法和治疗应用的最新进展。然而，吡嗪并吲哚的医学相关性要求开发通用且简单的新方法。本综述全面概述了基于吡嗪并吲哚的支架的合成方法和治疗应用的最新进展。然而，吡嗪并吲哚的医学相关性要求开发通用且简单的新方法。本综述全面概述了基于吡嗪并吲哚的支架的合成方法和治疗应用的最新进展。