PURPOSE The purpose of this study was to evaluate the predictive value of a 'Modified Karnofsky Scoring System' on outcomes and provide real-world data regarding the UK practice of biliary interventions. MATERIALS AND METHODS A prospective multi-centred cohort study was performed. The pre-procedure modified Karnofsky score, the incidence of sepsis, complications, biochemical improvement and mortality were recorded out to 30 days post procedure. RESULTS A total of 292 patients (248 with malignant lesions) were suitable for inclusion in the study. The overall 7 and 30 day mortality was 3.1% and 16.1%, respectively. The 30 day sepsis rate was 10.3%. In the modified Karnofsky 'high risk' group the 7 day mortality was 9.7% versus 0% for the 'low risk' group (p = 0.002), whereas the 30 day mortality was 28.8% versus 13.3% (p = 0.003). The incidence of sepsis at 30 days was 19% in the high risk group versus 3.3% at the low risk group (p = 0.001) CONCLUSION: Percutaneous biliary interventions in the UK are safe and effective. Scoring systems such as the Karnofsky or the modified Karnofsky score hold promise in allowing us to identify high risk groups that will need more careful consideration and enhanced patient informed consent but further research with larger studies is warranted in order to identify their true impact on patient selection and outcomes post biliary interventions.

中文翻译：

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影响经皮经肝胆道介入治疗结果的临床表现状态和技术因素；一项多中心、前瞻性、观察性队列研究。

目的 本研究的目的是评估“改良卡诺夫斯基评分系统”对结果的预测价值，并提供有关英国胆道干预实践的真实数据。材料和方法 进行了一项前瞻性多中心队列研究。术前修正的卡诺夫斯基评分、败血症的发生率、并发症、生化改善和死亡率被记录到术后 30 天。结果 共有 292 名患者（248 名患有恶性病变）适合纳入研究。7 天和 30 天的总体死亡率分别为 3.1% 和 16.1%。30天败血症率为10.3%。在改良卡诺夫斯基“高风险”组中，7 天死亡率为 9.7%，而“低风险”组为 0%（p = 0.002），而 30 天死亡率为 28.8% 和 13。3% (p = 0.003)。高危组 30 天脓毒症的发生率为 19%，低危组为 3.3%（p = 0.001） 结论：在英国，经皮胆道介入治疗是安全有效的。Karnofsky 或修改后的 Karnofsky 评分等评分系统有望使我们能够识别需要更仔细考虑和增强患者知情同意的高风险群体，但有必要通过更大规模的研究进行进一步研究，以确定它们对患者选择的真正影响和胆道干预后的结果。