MEKK1-dependent activation of the CRL4 complex is important for DNA damage-induced degradation of p21 and DDB2 and cell survival,Molecular and Cellular Biology

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MEKK1-dependent activation of the CRL4 complex is important for DNA damage-induced degradation of p21 and DDB2 and cell survival
Molecular and Cellular Biology ( IF 3.2 ) Pub Date : 2021-07-12 , DOI: 10.1128/mcb.00081-21
Susanne Bacher ₁ , Hilda Stekman ₁ , Carla M Farah ₁ , Annika Karger ₁ , Michael Kracht ₂ , M Lienhard Schmitz ₁

Affiliation

Cullin-4 ubiquitin ligase (CRL4) complexes are differentially composed and highly dynamic protein assemblies that control many biological processes including the global genome nucleotide excision repair (GG-NER) pathway. Here we identified the kinase ...

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