Examining the distribution and impact of single nucleotide polymorphisms in the capsular locus of Streptococcus pneumoniae serotype 19A,Infection and Immunity

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Examining the distribution and impact of single nucleotide polymorphisms in the capsular locus of Streptococcus pneumoniae serotype 19A
Infection and Immunity ( IF 2.9 ) Pub Date : 2021-07-12 , DOI: 10.1128/iai.00246-21
D W Arends ₁ , W R Miellet ₂ , J D Langereis ₁ , T H A Ederveen ₃ , C E van der Gaast-de Jongh ₁ , M van Scherpenzeel _{4,

5} , M J Knol ₂ , N M van Sorge ₆ , D J Lefeber ₅ , K Trzciński ₇ , E A M Sanders _{2,

7} , H C Dorfmueller ₈ , H J Bootsma _{1,

2} , M I de Jonge ₁

Affiliation

Laboratory of Medical Immunology, Radboud Center for Infectious Diseases, Radboud Institute for Molecular Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
National Institute for Public Health and the Environmentgrid.31147.30, Bilthoven, The Netherlands.
Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
GlycoMScan, Oss, The Netherlands.
Translational Metabolic Laboratory, Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Medical Microbiology and Infection Prevention, Netherlands Reference Laboratory for Bacterial Meningitis, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Division of Molecular Microbiology, School of Life Sciences, University of Dundeegrid.8241.f, Dundee, United Kingdom.

Streptococcus pneumoniae serotype 19A prevalence has increased after implementation of PCV7 and PCV10 vaccines. In this study, we have provided, with high accuracy, the genetic diversity of the 19A serotype in a cohort of Dutch invasive pneumococcal ...

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