BAFF is an essential cytokine primarily known for its role in maintaining B cell homeostasis via induction of a pro-survival gene expression profile. Additionally, recent evidence suggests that BAFF induced signaling also drives a metabolic program that is needed for homeostatic cell mass maintenance in resting B cells and which increases the cells' capacity to divide. Many components of the signaling cascades initiated by BAFF, the alternative NFκB pathway and the PI3K/AKT/mTOR pathway, are active in roles beyond their classically assigned function. These components can directly or indirectly impact metabolic reprogramming. Further exploration of the role BAFF signaling plays in B cell metabolism could help to identify metabolic vulnerabilities of hyperactive B cells in the context of autoimmunity.

中文翻译：

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B 细胞代谢中的 BAFF 信号传导。

BAFF 是一种重要的细胞因子，主要以其通过诱导促生存基因表达谱在维持 B 细胞稳态中的作用而闻名。此外，最近的证据表明，BAFF 诱导的信号传导还驱动了一种代谢程序，该程序是维持静息 B 细胞稳态细胞质量所需的，并增加了细胞分裂的能力。由 BAFF、替代 NFκB 途径和 PI3K/AKT/mTOR 途径启动的信号级联的许多成分在其经典指定功能之外的作用中发挥着积极作用。这些成分可以直接或间接影响代谢重编程。进一步探索 BAFF 信号在 B 细胞代谢中的作用可能有助于识别自身免疫背景下过度活跃的 B 细胞的代谢脆弱性。