The peptide repertoire presented by MHC class I molecules on the cell surface is essential for the immune surveillance of intracellular pathogens and transformed cells. The generation of this peptide repertoire is critically dependent on the endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP). Loss of ERAAP function leads to the generation of a profoundly disrupted peptide repertoire including many novel and immunogenic peptides. Strikingly, a large fraction of these novel peptides on ERAAP-KO cells are presented by the nonclassical MHC Ib molecule, Qa-1b. One immunodominant Qa-1b-restricted novel peptide is recognized by a unique CD8+ T cell population showing features of both conventional cytotoxic T cells and unconventional innate-like T cells. While much remains to be uncovered, here we summarize the latest discoveries of our lab on the important immune surveillance of ERAAP function mediated by nonclassical MHC Ib molecules and their unusual cognate T cells.

中文翻译：

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ERAAP 功能的非经典免疫监视。

MHC I 类分子在细胞表面呈递的肽库对于细胞内病原体和转化细胞的免疫监视至关重要。这种肽库的产生严重依赖于与抗原加工相关的内质网氨肽酶 (ERAAP)。ERAAP 功能的丧失导致产生严重破坏的肽库，包括许多新型和免疫原性肽。引人注目的是，ERAAP-KO 细胞上的这些新肽中有很大一部分是由非经典 MHC Ib 分子 Qa-1b 呈递的。一种免疫显性 Qa-1b 限制性新型肽被独特的 CD8+ T 细胞群识别，显示出常规细胞毒性 T 细胞和非常规先天样 T 细胞的特征。虽然还有很多东西有待发现，