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Longitudinal Functional Magnetic Resonance Spectroscopy Study in Subjects with Mild Cognitive Impairment and Alzheimer’s Disease
Current Alzheimer Research ( IF 1.8 ) Pub Date : 2021-03-31 , DOI: 10.2174/1567205018666210708145924
Soo-Hyun Cho 1 , Hak Y Rhee 2 , Janghoon Oh 3 , Jin S Lee 4 , Soonchan Park 5 , Won C Shin 2 , Jong-Woo Paik 6 , Chang-Woo Ryu 5 , Key C Park 4 , Geon-Ho Jahng 5
Affiliation  

Background: Longitudinal changes of brain metabolites during a functional stimulation are unknown in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) subjects.

Objective: This study was to evaluate the longitudinal changes of brain metabolites using proton magnetic resonance spectroscopy (1H MRS) in response to treatment during a memory task in the subjects of cognitive normal (CN), aMCI, and AD.

Methods: We acquired functional magnetic resonance spectroscopy (fMRS) data from 28 CN elderly, 16 aMCI and 12 AD subjects during a face-name association task. We measured fMRS metabolite ratios over 24 months in the 8-month apart, determined the temporal changes of the metabolites, and evaluated the differences among the three groups under the three different conditions (base, novel, repeat).

Results: The results of comparisons for the three subject groups and the three-time points showed that tNAA/tCho and tCr/tCho were statistically significant among the three subject groups in any of the three conditions. The dynamic temporal change measurements for the metabolites for each condition showed that Glx/tCho and Glu/tCho levels at the third visit increased significantly compared with in the first visit in the novel condition in the AD group.

Conclusion: We found declines in tNAA/tCho and tCr/tCho in the aMCI and AD subjects with increasing disease severity, being highest in CN and lowest in AD. The Glx/tCho level increased temporally in the AD subjects after they took an acetylcholine esterase inhibitor. Therefore, Glx may be suitable to demonstrate functional recovery after treatment.



中文翻译:

轻度认知障碍和阿尔茨海默病患者的纵向功能磁共振波谱研究

背景:在健忘性轻度认知障碍 (aMCI) 和阿尔茨海默病 (AD) 受试者中,功能刺激期间脑代谢物的纵向变化是未知的。

目的:本研究旨在使用质子磁共振波谱 (1H MRS) 评估认知正常 (CN)、aMCI 和 AD 受试者在记忆任务期间响应治疗的脑代谢物的纵向变化。

方法:我们在面部姓名关联任务中从 28 名 CN 老年人、16 名 aMCI 和 12 名 AD 受试者获得了功能磁共振波谱 (fMRS) 数据。我们在相隔 8 个月的时间内测量了 24 个月的 fMRS 代谢物比率,确定了代谢物的时间变化,并评估了在三种不同条件下(基础、新颖、重复)下三组之间的差异。

结果:三个受试者组和三个时间点的比较结果表明,tNAA/tCho 和 tCr/tCho 在三个受试者组中在三个条件中的任何一个中均具有统计学意义。每种条件下代谢物的动态时间变化测量表明,在 AD 组的新条件下,第三次访问时的 Glx/tCho 和 Glu/tCho 水平与第一次访问时相比显着增加。

结论:我们发现 aMCI 和 AD 受试者的 tNAA/tCho 和 tCr/tCho 随着疾病严重程度的增加而下降,在 CN 中最高,在 AD 中最低。服用乙酰胆碱酯酶抑制剂后,AD 受试者的 Glx/tCho 水平暂时增加。因此,Glx 可能适合证明治疗后的功能恢复。

更新日期:2021-03-31
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