PURPOSE To assess the incidence and risk factors of Descemet membrane detachment due to laser application in femtosecond laser-assisted cataract surgery (FLACS). METHODS In this retrospective case series, all patients who underwent FLACS with the LenSx system (Alcon Laboratories, Inc) were eligible to participate. The medical records were reviewed to collect data regarding potential risk factors related to Descemet membrane detachment, including patients' demographics, laser parameters, and ocular measurements. The eyes were separated into two groups based on the clinical diagnosis of Descemet membrane detachment as the femto-second laser was performing the corneal incisions. RESULTS Five hundred ten eyes (304 patients) were included. Descemet membrane detachment occurred in 20 (3.9%) eyes of 16 (5.3%) patients. Four (1.3%) patients had a detachment in both eyes. In 16 (3.1%) eyes, the Descemet membrane detachment occurred in the secondary incision site. The eyes that had a detachment had a statistically lower mean endothelial cell density (2,193.40 ± 313.37 versus 2,385.08 ± 357.80 cells/ mm2; P = .019), and a statistically higher prevalence of corneal guttata (25.0% versus 8.8%; P = .015). None of the other analyzed variables statistically differed between the groups (P > .05). The risk of having Descemet membrane detachment was statistically higher among eyes with guttata (odds ratio = 3.47; P = .015) and in those with an endothelial cell density of less than 2,000 cells/mm2 (odds ratio = 3.26; P = .014). CONCLUSIONS The incidence of Descemet membrane detachment due to laser application in FLACS was 3.9%, with the associated risk factors being endothelial cell density of less than 2,000 cells/mm2 and corneal guttata. [J Refract Surg. 2021;37(7):466-471.].

中文翻译：

---

飞秒激光辅助白内障手术中激光应用导致的后旋膜脱离：发生率和风险因素。

目的 评估飞秒激光辅助白内障手术 (FLACS) 中激光应用导致的 Descemet 膜脱离的发生率和危险因素。方法 在这个回顾性病例系列中，所有使用 LenSx 系统（Alcon Laboratories, Inc）接受 FLACS 的患者都有资格参与。审查医疗记录以收集与后旋塞膜脱离相关的潜在风险因素的数据，包括患者的人口统计学、激光参数和眼部测量。当飞秒激光进行角膜切口时，根据 Descemet 膜脱离的临床诊断将眼睛分为两组。结果 共纳入 510 只眼（304 名患者）。16 名 (5.3%) 患者的 20 只 (3.9%) 眼发生了 Descemet 膜脱离。四 (1。3%) 患者双眼有脱离。在 16 只（3.1%）眼中，后切面膜脱离发生在二次切口部位。有脱离的眼睛具有统计学上较低的平均内皮细胞密度（2,193.40 ± 313.37 对 2,385.08 ± 357.80 个细胞/ mm2；P = .019），并且角膜滴虫的患病率在统计学上更高（25.0% 对 8.8%；P = . 015)。其他分析变量在组间没有统计学差异（P > .05）。在滴眼液（优势比 = 3.47；P = .015）和内皮细胞密度低于 2,000 个细胞/mm2（优势比 = 3.26；P = .014）的眼睛中，Descemet 膜脱离的风险在统计学上更高）。结论 在 FLACS 中激光应用引起的 Descemet 膜脱离的发生率为 3.9%，相关的危险因素是内皮细胞密度低于 2,000 个细胞/mm2 和角膜滴虫。[J 屈光手术。2021;37(7):466-471.]。