PURPOSE To compare attempted versus achieved corneal stromal thickness reduction in a consecutive case series of patients undergoing laser in situ keratomileusis (LASIK) in one eye and small incision lenticule extraction (SMILE) in the other eye. METHODS This prospective, randomized, contralateral eye study included 22 consecutive patients (44 eyes), one eye randomized to have myopic LASIK and the contralateral eye to have SMILE. Anterior segment optical coherence tomography was performed preoperatively and at 3 months postoperatively. For each of the treatment groups, the achieved maximum stromal thickness reduction was compared to the planned/attempted thickness. The deviation of planned versus achieved stromal thickness reduction was then compared between the two groups. RESULTS At 3 months postoperatively, LASIK had a lower difference between planned versus attempted stromal thickness reduction compared to SMILE (13.72 ± 14.45 vs 24.00 ± 19.45 µm, P = .03). Graphical analysis revealed this deviation to be exaggerated in higher myopic errors, when a higher maximum stromal reduction was planned. The mean stromal reduction thickness was 83.40 ± 29.52 µm achieved versus 97.13 ± 25.69 µm mean planned ablation depth in the LASIK group (P < .001) compared to 76.45 ± 29.69 µm achieved versus 100.45 ± 26.56 µm planned ablation depth in the SMILE group (P < .001). CONCLUSIONS LASIK had a significantly lower difference between planned versus achieved stromal thickness reduction when compared to SMILE (P = .03). This difference was more apparent in higher myopic corrections. [J Refract Surg. 2021;37(7):454-459.].

中文翻译：

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LASIK 与 SMILE 中计划与实现中央基质厚度减少的比较：对侧眼研究。

目的 比较连续病例系列患者的角膜基质厚度减少尝试与实现，其中一只眼接受激光原位角膜磨镶术 (LASIK)，另一只眼接受小切口微透镜提取术 (SMILE)。方法 这项前瞻性、随机、对侧眼研究包括 22 名连续患者（44 只眼），其中一只眼随机接受近视 LASIK，另一只眼随机接受 SMILE。术前和术后 3 个月进行了前段光学相干断层扫描。对于每个治疗组，将实现的最大基质厚度减少与计划/尝试的厚度进行比较。然后比较两组之间计划与实现的基质厚度减少的偏差。结果 术后 3 个月，与 SMILE 相比，LASIK 计划与尝试减少基质厚度之间的差异较小（13.72 ± 14.45 与 24.00 ± 19.45 µm，P = .03）。图形分析显示，当计划进行更高的最大基质减少时，这种偏差在更高的近视误差中被夸大。LASIK 组的平均基质减少厚度为 83.40 ± 29.52 µm，而 LASIK 组的平均计划消融深度为 97.13 ± 25.69 µm（P < .001），相比之下，达到的 76.45 ± 29.69 µm 与 100.45 ± 26.56 µm 的 SMI 手术组计划的消融深度相比P < .001）。结论与 SMILE 相比，LASIK 计划与实现的基质厚度减少之间的差异显着较低（P = .03）。这种差异在高度近视矫正中更为明显。[J 屈光手术。2021;37(7):454-459.]。