OBJECTIVE Thyroid surgery may lead to postoperative complications. The aim of this paper was to determine whether the rate of postoperative hypoparathyroidism (HPT) is influenced by whether surgery is staged. DESIGN Single-institution retrospective observational study. METHODS The clinical records of 786 patients treated at the Otolaryngology Unit of the Azienda USL-IRCCS di Reggio Emilia between January 1990 and December 2015 were reviewed. Patients were divided into two groups according to the surgical treatment received: group TT (637 patients, 81.04%) underwent single-stage total thyroidectomy; Group cT (149 patients, 18.96%) underwent loboisthmusectomy and delayed completion total thyroidectomy. Transient and permanent HPT, assessed after 6 months of follow-up, were the primary endpoints. Risk factors of postoperative HPT were also analysed as secondary outcomes. RESULTS Rates of transient HPT in group TT were higher than those observed in group cT, (P = 0.0057). Analysis of risk factors identified sex as an independent risk factor for transient HPT only for group TT (P = 0.0012) and the number of parathyroid glands remaining in situ (PGRIS) as an independent risk factor for transient and permanent HPT for group TT (P < 0.0001 and P = 0.0002, respectively). CONCLUSIONS This study suggests that the risk of transient postoperative HPT is lower in patients that undergo completion thyroidectomy. Further independent risk factors for postoperative HPT are female sex and PGRIS score. In light of the growing use of conservative surgery for thyroid neoplasms, these findings could help to adequately plan surgery in order to reduce endocrine complications.

中文翻译：

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高分化甲状腺癌完成甲状腺切除术后的术后甲状旁腺功能减退。

目的甲状腺手术可能导致术后并发症。本文的目的是确定术后甲状旁腺功能减退症（HPT）的发生率是否受手术是否分期的影响。设计 单机构回顾性观察研究。方法 回顾 1990 年 1 月至 2015 年 12 月期间在 Azienda USL-IRCCS di Reggio Emilia 耳鼻喉科治疗的 786 名患者的临床记录。根据接受的手术治疗情况分为两组：TT组（637例，81.04%）接受单期全甲状腺切除术；cT 组（149 名患者，18.96%）接受了叶状峡部切除术和延迟完成的全甲状腺切除术。在 6 个月的随访后评估的暂时性和永久性 HPT 是主要终点。术后 HPT 的危险因素也作为次要结果进行分析。结果 TT 组的瞬时 HPT 发生率高于 cT 组（P = 0.0057）。风险因素分析发现，性别仅是 TT 组短暂性 HPT 的独立危险因素（P = 0.0012），原位甲状旁腺数量（PGRIS）是 TT 组短暂性和永久性 HPT 的独立危险因素（P < 0.0001 和 P = 0.0002，分别）。结论 本研究表明，接受完整甲状腺切除术的患者发生短暂性术后 HPT 的风险较低。术后 HPT 的其他独立危险因素是女性和 PGRIS 评分。鉴于越来越多地使用保守手术治疗甲状腺肿瘤，