FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair,Molecular and Cellular Biology

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FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair
Molecular and Cellular Biology ( IF 3.2 ) Pub Date : 2021-08-24 , DOI: 10.1128/mcb.00303-21
Katja Kratz ₁ , Mariela Artola-Borán ₁ , Saho Kobayashi-Era _{1,

2} , Gene Koh _{3,

4,

5} , Goncalo Oliveira ₆ , Shunsuke Kobayashi _{1,

2} , Andreia Oliveira _{1,

2} , Xueqing Zou _{3,

4,

5} , Julia Richter ₂ , Masataka Tsuda ₇ , Hiroyuki Sasanuma ₇ , Shunichi Takeda ₇ , Joanna I Loizou ₆ , Alessandro A Sartori ₁ , Serena Nik-Zainal _{4,

5} , Josef Jiricny _{1,

2}

Affiliation

Germline mutations in the mismatch repair (MMR) genes MSH2, MSH6, MLH1, and PMS2 are linked to cancer of the colon and other organs, characterized by microsatellite instability and a large increase in mutation frequency. Unexpectedly, mutations in EXO1, ...

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