Although epicardial adipose tissue (EAT) and abdominal visceral adipose tissue (VAT) can contribute to left ventricular diastolic dysfunction (LVDD), the impact of these distribution has not been fully understood. A total of 235 patients who underwent cardiac computed tomography angiography and Doppler echocardiography was included in this study. We evaluated the association of indexed EAT volume and VAT area with septal and lateral early diastolic mitral annular velocity (e′). The VAT area index was significantly associated with septal and lateral e′ velocity after adjusted for conventional cardiovascular risk factors and obstructive coronary artery disease (β-estimate; − 0.015 and − 0.019, both p = 0.01). The natural logarithmic EAT volume index (ln EAT volume index) also showed a significant association with septal and lateral e′ (β-estimate; − 1.72 and − 0.99, both p < 0.01). The significant association of ln EAT volume index with septal and lateral e′ was observed even after adjusting for VAT area index (β-estimate; − 0.79 and − 1.52, both p < 0.03). In the subgroup analysis, there were significant association of ln EAT volume index with both septal and lateral e′ in the lower VAT group (β-estimate; − 1.40 and − 1.53, both p < 0.03) and with lateral e′ in the higher VAT group (β-estimate − 1.64, p = 0.006). In contrast, ln EAT volume index was not associated with septal e′ in the higher VAT group (p = 0.98). EAT accumulation was significantly associated with LVDD independently of obstructive coronary artery disease and abdominal VAT. The impact of EAT on LVDD may vary depending on the amount of abdominal VAT.

尽管心外膜脂肪组织 (EAT) 和腹部内脏脂肪组织 (VAT) 可导致左心室舒张功能障碍 (LVDD)，但这些分布的影响尚未完全了解。本研究共纳入 235 例接受心脏 CT 血管造影和多普勒超声心动图检查的患者。我们评估了指数 EAT 体积和 VAT 面积与间隔和舒张早期二尖瓣环外侧速度 ( e ') 的关联。在调整常规心血管危险因素和阻塞性冠状动脉疾病后，VAT 面积指数与间隔和侧向e ' 速度显着相关（ β估计；- 0.015 和 - 0.019，均p = 0.01)。自然对数 EAT 体积指数（ln EAT 体积指数）也显示出与间隔和侧向e ' 的显着相关性（β-估计；- 1.72 和 - 0.99，均p  < 0.01）。即使在调整 VAT 面积指数后，也观察到ln EAT 体积指数与间隔和侧向e ' 的显着关联（ β-估计；- 0.79 和 - 1.52，均p  < 0.03）。在亚组分析中，低 VAT 组的 ln EAT 体积指数与间隔和侧向e ' 显着相关（ β-估计；- 1.40 和 - 1.53，均p  < 0.03）和侧向e' 在较高增值税组中（β-估计 - 1.64，p  = 0.006）。相比之下，ln EAT 体积指数与较高 VAT 组的间隔e ' 无关（ p  = 0.98）。EAT 积累与 LVDD 显着相关，与阻塞性冠状动脉疾病和腹部 VAT 无关。EAT 对 LVDD 的影响可能因腹部增值税的量而异。