Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen,mBio

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Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen
mBio ( IF 5.1 ) Pub Date : 2021-07-06 , DOI: 10.1128/mbio.02531-20
Ilona Rissanen _{1,

2,

3} , Stefanie A Krumm ₄ , Robert Stass ₁ , Annalis Whitaker _{5,

6} , James E Voss ₇ , Emily A Bruce _{5,

8} , Sylvia Rothenberger ₉ , Stefan Kunz ₉ , Dennis R Burton _{7,

10} , Juha T Huiskonen _{1,

2,

3} , Jason W Botten _{5,

8} , Thomas A Bowden ₁ , Katie J Doores ₄

Affiliation

Division of Structural Biology, Wellcome Centre for Human Genetics, grid.4991.5University of Oxford, Oxford, United Kingdom.
Institute of Biotechnology and Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Department of Infectious Diseases, King's College London, London, United Kingdom.
Division of Immunobiology, Department of Medicine, Larner College of Medicine, grid.59062.38University of Vermont, Burlington, Vermont, USA.
Cellular, Molecular, and Biomedical Sciences Graduate Program, grid.59062.38University of Vermont, Burlington, Vermont, USA.
Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA.
Department of Microbiology and Molecular Genetics, Larner College of Medicine, grid.59062.38University of Vermont, Burlington, Vermont, USA.
Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Ragon Institute of MGH, Harvard, and MIT, Cambridge, Massachusetts, USA.

The spillover of pathogenic hantaviruses from rodent reservoirs into the human population poses a continued threat to human health. Here, we show that a recombinant form of the Hantaan virus (HTNV) surface-displayed glycoprotein, Gn, elicits a ...

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