AIM Compare a pre-co-seasonal with a perennial schedule using an undiluted mixture of a depigmented-polymerized grass/Olea europaea immunotherapy (2,000 DPP/mL) in pediatric patients with rhinitis/rhinoconjunctivitis with or without controlled asthma. MATERIAL AND METHODS Primary objective was to determine the non-superiority of a perennial compared to a pre-co-seasonal schedule by means of Paediatric/Adolescent Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ/AdolRQLQ). Secondary objectives were Paediatric Asthma/Caregiver´s Quality of Life Questionnaire (PAQLQ/PACQLQ) Asthma Control Test (ACT), Visual Analogue Scale global assessment of allergic disease (VAS), use of resources and immunological response. All variables were compared during the pollen season (April-June) without (2015) and with (2016) immunotherapy. RESULTS Forty patients were included in the study of which 29 patients were assigned to the perennial and 11 to the pre-co-seasonal schedule. During 2016 pollen season a significant improvement in the PRQLQ/AdolRQLQ, PAQLQ/AdolAQLQ, ACT and VAS score were observed both in perennial and pre-co-seasonal schedule group. No significant differences were seen between treatment schedules for PRQLQ/AdolRQLQ, PAQLQ/AdolAQLQ and ACT scores comparing both pollen seasons. A significant increase in sIgG4 and reduction in the number of rescue medications used and number of patients who needed visit to any specialist was observed in both treatment schedules during 2016 pollen season. No relevant differences were found in the safety profile of any treatment schedule. DISCUSSION Treatment with undiluted mixture of a depigmented-polymerized Grass/Olea europaea allergen immunotherapy has proven to be effective both using a perennial and a pre-co-seasonal schedule and therefore suitable for polyallergic patients.

中文翻译：

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评估儿科患者单一多过敏原脱色聚合皮下免疫治疗的季节性前和常年时间表。

AIM 比较使用脱色聚合草/油橄榄免疫疗法 (2,000 DPP/mL) 的未稀释混合物治疗患有或未控制哮喘的鼻炎/鼻结膜炎的儿科患者的季节性前与常年性时间表。材料和方法 主要目标是通过儿科/青少年鼻结膜炎生活质量问卷 (PRQLQ/AdolRQLQ) 确定多年生植物与同季前时间表相比的非优越性。次要目标是小儿哮喘/护理人员生活质量问卷 (PAQLQ/PACQLQ) 哮喘控制测试 (ACT)、过敏性疾病 (VAS) 视觉模拟量表全球评估、资源使用和免疫反应。在没有（2015 年）和（2016 年）免疫疗法的花粉季节（4 月至 6 月）期间比较了所有变量。结果 40 名患者被纳入研究，其中 29 名患者被分配到常年，11 名患者被分配到同季前计划。在 2016 年花粉季节期间，常年和季前计划组的 PRQLQ/AdolRQLQ、PAQLQ/AdolAQLQ、ACT 和 VAS 评分都有显着改善。比较两个花粉季节的 PRQLQ/AdolRQLQ、PAQLQ/AdolAQLQ 和 ACT 评分的治疗方案之间没有显着差异。在 2016 年花粉季节的两种治疗方案中，都观察到 sIgG4 显着增加，使用的急救药物数量和需要就诊专家的患者数量减少。在任何治疗方案的安全性方面均未发现相关差异。