Cells are exposed to a variety of mechanical cues, including forces from their local environment and physical properties of the tissue. These mechanical cues regulate a vast number of cellular processes, relying on a repertoire of mechanosensors that transduce forces into biochemical pathways through mechanotransduction. Forces can act on different parts of the cell, carry information regarding magnitude and direction, and have distinct temporal profiles. Thus, the specific cellular response to mechanical forces is dependent on the ability of cells to sense and transduce these physical parameters. In this review, we will highlight recent findings that provide insights into the mechanisms by which different mechanosensors decode mechanical cues and how their coordinated response determines the cellular outcomes.

中文翻译：

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通过分子机械转导解码机械线索。

细胞暴露于各种机械线索，包括来自其局部环境的力和组织的物理特性。这些机械线索调节大量细胞过程，依赖于通过机械转导将力转化为生化途径的机械传感器库。力可以作用于细胞的不同部分，携带有关大小和方向的信息，并具有不同的时间分布。因此，细胞对机械力的特定反应取决于细胞感知和转导这些物理参数的能力。在这篇综述中，我们将重点介绍最近的发现，这些发现提供了对不同机械传感器解码机械线索的机制以及它们的协调反应如何决定细胞结果的见解。