Molecular imaging is a valuable tool in drug discovery and development, early screening and diagnosis of diseases, and therapy assessment among others. Although many different imaging modalities are in use today, molecular imaging with computed tomography (CT) is still challenging owing to its low sensitivity and soft tissue contrast compared with other modalities. Recent technical advances, particularly the introduction of spectral photon-counting detectors, might allow overcoming these challenges. Herein, the fundamentals and recent advances in CT relevant to molecular imaging are reviewed and potential future preclinical and clinical applications are highlighted. The review concludes with a discussion of potential future advancements of CT for molecular imaging.

中文翻译：

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使用光谱光子计数计算机断层扫描进行分子成像？

分子成像是药物发现和开发、疾病的早期筛查和诊断以及治疗评估等方面的宝贵工具。尽管今天使用了许多不同的成像方式，但与其他方式相比，计算机断层扫描 (CT) 的分子成像仍然具有挑战性，因为它的灵敏度和软组织对比度较低。最近的技术进步，特别是光谱光子计数探测器的引入，可能有助于克服这些挑战。在此，回顾了与分子成像相关的 CT 的基本原理和最新进展，并强调了未来潜在的临床前和临床应用。该评论最后讨论了 CT 在分子成像方面的潜在未来发展。