Phospholipids reportedly alleviate drug-induced acute kidney injury. However, no study has compared the effect of phospholipids with different fatty acids and polar heads on drug-induced nephrotoxicity. In the present study, we aimed to compare the possible nephroprotection afforded by phosphatidylcholine and phosphatidylserine with different fatty acids in a mouse model of vancomycin-induced nephrotoxicity. Pretreatment with phospholipids rich in docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) doubled the survival time when compared with the model group. Moreover, phospholipids rich in DHA/EPA significantly reduced the serum levels of renal function biomarkers and ameliorated kidney pathologies. In terms of alleviating renal damage, no significant differences were observed between different polar heads in DHA-enriched phospholipids, while phosphatidylserine from soybean was better than phosphatidylcholine in mitigating renal injury. Furthermore, DHA/EPA-enriched phospholipids inhibited vancomycin-induced nephrotoxicity mainly by inhibiting apoptosis and oxidative stress. These results provide a scientific basis for phospholipids as potential ingredients to prevent acute kidney injury.

中文翻译：

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磷脂酰胆碱和磷脂酰丝氨酸与不同脂肪酸对万古霉素诱导小鼠肾毒性的比较评价。

据报道，磷脂可减轻药物引起的急性肾损伤。然而，没有研究比较不同脂肪酸和极性头的磷脂对药物引起的肾毒性的影响。在本研究中，我们旨在比较磷脂酰胆碱和磷脂酰丝氨酸与不同脂肪酸在万古霉素诱导的肾毒性小鼠模型中可能提供的肾保护作用。与模型组相比，用富含二十二碳六烯酸 (DHA) 或二十碳五烯酸 (EPA) 的磷脂进行预处理可使存活时间增加一倍。此外，富含 DHA/EPA 的磷脂显着降低了肾功能生物标志物的血清水平并改善了肾脏病理。在减轻肾脏损害方面，富含 DHA 的磷脂在不同极头之间没有观察到显着差异，而大豆磷脂酰丝氨酸在减轻肾损伤方面优于磷脂酰胆碱。此外，富含 DHA/EPA 的磷脂主要通过抑制细胞凋亡和氧化应激来抑制万古霉素诱导的肾毒性。这些结果为磷脂作为预防急性肾损伤的潜在成分提供了科学依据。