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Antioxidant Properties of a Nanostructured Clathrate Complex Selenopyran with β-Cyclodextrin in Model Systems of Oxidative Stress.
Bulletin of Experimental Biology and Medicine ( IF 0.9 ) Pub Date : 2021-06-26 , DOI: 10.1007/s10517-021-05204-5
L A Dzikovskaya 1 , E S Degtyareva 1 , P V Shegai 1 , S A Ivanov 1 , A D Kaprin 1
Affiliation  

We studied the effect of nanostructured clathrate complex 9-phenyl-symm-octahydoselenoxanthene (selenopyran) with β-cyclodextrin on the generation of ОН· radicals in the Fenton system and parameters of oxidative stress in rat liver cells incubated at 37°С for 1 h. The complex inhibits the development of free-radical oxidative processes induced by ROS and the most toxic ОН· radicals, reduces the increased level of ROS induced by prooxidants, and exhibits antioxidant activity.

中文翻译:


纳米结构笼形复合物硒吡喃与 β-环糊精在氧化应激模型系统中的抗氧化特性。



我们研究了纳米结构笼形复合物 9-苯基-对称-八氢硒杂蒽(硒代吡喃)与 β-环糊精对 Fenton 系统中 ОН·自由基生成的影响以及在 37°С 孵育 1 小时的大鼠肝细胞中氧化应激参数。该复合物可抑制 ROS 和毒性最强的 ОН· 自由基诱导的自由基氧化过程的发展,降低促氧化剂诱导的 ROS 水平升高,并具有抗氧化活性。
更新日期:2021-06-26
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