In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organo-hydrogels containing pH-sensitive Agar (A), Glycerol (G), Sweet Almond oil (Wu et al. in J Mol Struct 882:107-115, 2008). Organo-hydrogels, which contained Agar, Glycerol and different amounts of Sweet Almond oil, were synthesized via the free-radical polymerization reaction with emulsion technique using glutaraldehyde or methylene bis acrylamide crosslinkers. Then, the degree of swelling, bond structures, blood compatibility and antioxidant properties of the synthesized organo-hydrogels were examined. In addition, Organo-hydrogels which loaded with Ceftriaxone and Oxaliplatin were synthesized with the same polymerization reaction and release kinetics were investigated. In vitro release studies were performed at media similar pH to gastric fluid (pH 2.0), skin surface (pH 5.5), blood fluid (pH 7.4) and intestinal fluid (pH 8.0), at 37 °C. The effects on release of crosslinker type and sweet almond oil amount were investigated. Kinetic parameters were determined using release results and these results were applied to zero and first-order equations and Korsmeyer-Peppas and Higuchi equations. Diffusion exponential was calculated for drug diffusion of organo-hydrogels and values consistent with release results were found.

中文翻译：

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基于聚（琼脂-共-甘油-共-甜杏仁油）的有机水凝胶作为药物递送材料的应用。

在本研究中，旨在研究含有 pH 敏感琼脂 (A)、甘油 (G)、甜杏仁油的有机水凝胶的合成、表征和药物释放行为（Wu et al. in J Mol Struct 882:107 -115，2008）。使用戊二醛或亚甲基双丙烯酰胺交联剂，通过自由基聚合反应和乳液技术合成了含有琼脂、甘油和不同量甜杏仁油的有机水凝胶。然后，检查了合成的有机水凝胶的溶胀度、键结构、血液相容性和抗氧化性能。此外，以相同的聚合反应合成了负载头孢曲松和奥沙利铂的有机水凝胶，并研究了释放动力学。在与胃液 (pH 2.0)、皮肤表面 (pH 5.5)、血液 (pH 7.4) 和肠液 (pH 8.0) 相近的介质中，在 37 °C 下进行体外释放研究。研究了交联剂类型和甜杏仁油用量对释放的影响。使用释放结果确定动力学参数，并将这些结果应用于零和一阶方程以及 Korsmeyer-Peppas 和 Higuchi 方程。计算有机水凝胶药物扩散的扩散指数，发现与释放结果一致的值。使用释放结果确定动力学参数，并将这些结果应用于零和一阶方程以及 Korsmeyer-Peppas 和 Higuchi 方程。计算有机水凝胶药物扩散的扩散指数，发现与释放结果一致的值。使用释放结果确定动力学参数，并将这些结果应用于零和一阶方程以及 Korsmeyer-Peppas 和 Higuchi 方程。计算有机水凝胶药物扩散的扩散指数，发现与释放结果一致的值。