PURPOSE To report the clinical outcomes of combined sparing laser photocoagulation and intravitreal bevacizumab treatment compared to conventional laser photocoagulation for the treatment of aggressive posterior retinopathy of prematurity (APROP). METHODS A medical chart review was performed on all consecutive eyes with APROP that were treated with conventional laser photocoagulation or laser photocoagulation and intravitreal bevacizumab (IVB) injection between July 2019 and August 2020. The data were recorded for time to reversal of plus disease, time to total regression of retinopathy of prematurity (ROP) after intervention, total laser spots and area, proportion of eyes with satisfactory anatomical outcomes, and adverse events. Outcomes of the two groups were compared. RESULTS Sixteen eyes of 8 infants with APROP were included in the analysis. Eight eyes of 4 infants received combined sparing laser photocoagulation and IVB treatment, and 8 eyes of 4 infants received conventional laser photocoagulation. All 8 eyes in the combined treatment group and 6 of 8 eyes in the conventional treatment group showed regression of ROP with a satisfactory anatomical outcome. The average time to total regression of ROP was 34 days in the combined treatment group and 56 days in the conventional treatment group (P = .005). The number of laser spots was significantly lower in the combined treatment group (P = .03). CONCLUSIONS Combined sparing laser photocoagulation and IVB treatment for eyes with APROP achieved ROP regression twice as fast, had fewer laser spots, and had a satisfactory anatomical outcome in comparison to conventional laser photocoagulation. [J Pediatr Ophthalmol Strabismus. 2021;58(5):292-297.].

中文翻译：

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联合备用激光光凝术和玻璃体内贝伐单抗治疗与传统激光光凝术治疗早产儿侵袭性后部视网膜病变的结果比较。

目的 报告与传统激光光凝术相比，联合保留激光光凝术和玻璃体内贝伐珠单抗治疗治疗侵袭性早产儿视网膜病变 (APROP) 的临床结果。方法 对 2019 年 7 月至 2020 年 8 月期间接受常规激光光凝术或激光光凝术和玻璃体内贝伐珠单抗 (IVB) 注射治疗的所有连续 APROP 眼进行病历审查。干预后早产儿视网膜病变 (ROP) 的完全消退、总激光点和面积、具有令人满意的解剖结果的眼睛比例以及不良事件。比较两组的结果。结果 8 名 APROP 婴儿的 16 只眼被纳入分析。4例婴儿8眼接受保留激光光凝联合IVB治疗，4例婴儿8眼接受常规激光光凝治疗。联合治疗组 8 只眼和常规治疗组 8 只眼中的 6 只眼均显示 ROP 消退，解剖结果令人满意。联合治疗组 ROP 完全消退的平均时间为 34 天，常规治疗组为 56 天 (P = .005)。联合治疗组的激光点数量显着减少（P = .03）。结论 与传统激光光凝术相比，APROP 联合备用激光光凝术和 IVB 治疗眼的 ROP 回归速度是其两倍，具有更少的激光光斑，并且具有令人满意的解剖结果。[J Pediatr Ophthalmol 斜视。2021；58(5)：