We evaluated whether hair products, which may contain carcinogens and endocrine disruptors that can be absorbed into the bloodstream, are related to ovarian cancer incidence in a prospective cohort. After excluding women with a history of ovarian cancer or bilateral oophorectomy, 40 559 Sister Study participants ages 35-74 at enrollment (2003-2009) were included. Participants completed questionnaires on hair product use, including hair dyes, straighteners/relaxers and permanents/body waves, in the past 12 months. Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between hair products and incident ovarian cancer. We assessed associations stratified by tumor type (serous, non-serous). Over a mean follow-up of 10 years, 241 women were diagnosed with ovarian cancer. Ever use of any of the examined hair products during the past year was not associated with ovarian cancer risk. However, frequent use (>4 times/year) of straighteners/relaxers or pressing products in the past year was associated with an increased risk of ovarian cancer (HR = 2.19, 95% CI: 1.12-4.27). Ever use of permanent hair dye was positively associated with non-serous (HR = 1.94, 95% CI 1.12-3.37), but inversely associated with serous (HR = 0.65, 95% CI: 0.43-0.99) tumors (p-for-heterogeneity = 0.002). Our novel findings suggest that frequent use of hair straighteners/relaxers or pressing products, which are primarily used by African American/Black women, and possibly permanent hair dye, may be associated with the occurrence of ovarian cancers.

中文翻译：

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使用护发产品与卵巢癌风险相关。

我们在前瞻性队列中评估了可能含有致癌物质和可被吸收到血液中的内分泌干扰物的护发产品是否与卵巢癌发病率相关。在排除有卵巢癌或双侧卵巢切除史的女性后，纳入了 40 559 名姐妹研究参与者（2003-2009 年），年龄在 35-74 岁之间。参与者在过去 12 个月内完成了有关护发产品使用情况的调查问卷，包括染发剂、直发器/直发器和烫发器/卷发器。Cox 回归用于估计护发产品与卵巢癌之间关联的调整后风险比 (HR) 和 95% 置信区间 (CI)。我们评估了按肿瘤类型（浆液性、非浆液性）分层的关联性。经过平均 10 年的随访，241 名女性被诊断患有卵巢癌。过去一年中使用过任何受检查的护发产品与卵巢癌风险无关。然而，过去一年频繁使用（>4 次/年）直发器/松弛器或熨烫产品与卵巢癌风险增加相关（HR = 2.19，95% CI：1.12-4.27）。曾经使用过永久性染发剂与非浆液性肿瘤呈正相关（HR = 1.94，95% CI 1.12-3.37），但与浆液性肿瘤呈负相关（HR = 0.65，95% CI：0.43-0.99）（p-for-异质性 = 0.002)。我们的新发现表明，频繁使用直发器/直发器或烫发产品（主要由非裔美国/黑人女性使用）以及可能的永久性染发剂可能与卵巢癌的发生有关。