We showed that the isobutanol sensitivity in glucose-6-phosphate dehydrogenase-deficient cells of the yeast Saccharomyces cerevisiae was rescued by an alternative NADPH producer, acetaldehyde dehydrogenase, but not in the cells lacking 6-phosphogluconate dehydrogenase. This phenotype correlated with the intracellular NADPH/NADP+ ratio in yeast strains. Our findings indicate the importance of NADPH for the isobutanol tolerance of yeast cells.

中文翻译：

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NADPH 对酿酒酵母基本培养基中的异丁醇耐受性很重要。

我们发现，酿酒酵母的葡萄糖-6-磷酸脱氢酶缺陷细胞中的异丁醇敏感性被另一种 NADPH 生产者乙醛脱氢酶拯救，但在缺乏 6-磷酸葡萄糖酸脱氢酶的细胞中则不然。这种表型与酵母菌株中的细胞内 NADPH/NADP+ 比率相关。我们的研究结果表明 NADPH 对酵母细胞异丁醇耐受性的重要性。