Background One year after the declaration of the coronavirus disease 2019 (COVID-19) pandemic by the World Health Organization (WHO) and despite the implementation of mandatory physical barriers and social distancing, humanity remains challenged by a long-lasting and devastating public health crisis. Management Non-pharmacological interventions (NPIs) are efficient mitigation strategies. The success of these NPIs is dependent on the approval and commitment of the population. The launch of a mass vaccination program in many countries in late December 2020 with mRNA vaccines, adenovirus-based vaccines, and inactivated virus vaccines has generated hope for the end of the pandemic. Current Issues The continuous appearance of new pathogenic viral strains and the ability of vaccines to prevent infection and transmission raise important concerns as we try to achieve community immunity against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and its variants. The need of a second and even third generation of vaccines has already been acknowledged by the WHO and governments. Perspectives There is a critical and urgent need for a balanced and integrated strategy for the management of the COVID-19 outbreaks organized on three axes: (1) Prevention of the SARS-CoV-2 infection, (2) Detection and early diagnosis of patients at risk of disease worsening, and (3) Anticipation of medical care (PDA). Conclusion The “PDA strategy” integrated into state policy for the support and expansion of health systems and introduction of digital organizations (i.e., telemedicine, e-Health, artificial intelligence, and machine-learning technology) is of major importance for the preservation of citizens' health and life world-wide.

中文翻译：

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COVID-19 大流行和需要采取综合和公平的方法：国际专家共识文件

背景 在世界卫生组织 (WHO) 宣布 2019 年冠状病毒病 (COVID-19) 大流行一年后，尽管实施了强制性的物理障碍和社会疏离，但人类仍然受到长期和毁灭性的公共卫生危机的挑战. 管理 非药物干预 (NPI) 是有效的缓解策略。这些 NPI 的成功取决于民众的认可和承诺。2020 年 12 月下旬在许多国家启动了大规模疫苗接种计划，包括 mRNA 疫苗、基于腺病毒的疫苗和灭活病毒疫苗，这为大流行的结束带来了希望。当前问题 随着我们努力实现针对严重急性呼吸综合征冠状病毒 2 型 (SARS-CoV-2) 及其变体的社区免疫，新的致病病毒株的不断出现以及疫苗预防感染和传播的能力引起了人们的重要关注。世界卫生组织和各国政府已经认识到需要第二代甚至第三代疫苗。观点 迫切需要一个平衡和综合的战略来管理 COVID-19 暴发，从三个方面组织：(1) 预防 SARS-CoV-2 感染，(2) 检测和早期诊断患者有疾病恶化的风险，以及 (3) 预期医疗护理 (PDA)。