Cancer development and progression is often associated with inflammation. Late diagnosis of inflammation that directly leads to the development of neoplasm—cancer is associated with a reduction in the chance of successful treatment or is associated with therapeutic difficulties. A panel of chromogenic substrates was used for the qualitative determination of the specific activity of enzymes in urine of patients with confirmed inflammatory reaction and/or epithelial neoplasms in particular tumours at various stages of development. Urine of people with excluded inflammation was used as a control group. Proteolytic activity was determined in urine samples collected from patients with epithelial neoplasms and/or inflammation. What is more, we determine human neutrophil elastase activity-related inflammation based on the examination of urine samples. We suspect that the proteolytical activity of urine samples is due to neutrophil response to inflammation, which is directly related to cancer. This is the first study to determine elastolytic activity in bladder cancer urine samples. It supports wider use of urine for inflammation screening.

中文翻译：

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弹性溶解活性与膀胱癌的炎症有关

癌症的发展和进展通常与炎症有关。直接导致肿瘤发展的炎症的晚期诊断——癌症与成功治疗的机会减少或与治疗困难有关。一组显色底物用于定性测定具有确认的炎症反应和/或上皮肿瘤，特别是处于不同发展阶段的肿瘤的患者尿液中酶的比活性。排除炎症的人的尿液作为对照组。在从患有上皮肿瘤和/或炎症的患者收集的尿样中测定蛋白水解活性。更重要的是，我们根据尿液样本的检查确定人类中性粒细胞弹性蛋白酶活性相关的炎症。我们怀疑尿液样本的蛋白水解活性是由于中性粒细胞对炎症的反应，而炎症与癌症直接相关。这是第一项确定膀胱癌尿液样本中弹性溶解活性的研究。它支持更广泛地使用尿液进行炎症筛查。