Aim: Being the common cause and major burden of deaths globally, timely cancer management is crucial.

Background: Thymic immunosuppressive pentapeptide (TIPP) is a novel pentapeptide originally obtained from calf thymic immunosuppressive extract. Previously, TIPP has been proved to suppress the allergic and inflammatory responses in allergic mice via blocking MAP kinases/NF-κB signaling pathways.

Objective: In this study, in vitro anticancer activity of TIPP was tested on two different types of cancers using MCF-7 and K562 cell lines.

Methods: Tumor xenograft models for breast cancer and chronic myeloid leukemia were designed. In vivo anticancer activity of TIPP was investigated on both cancer types. The liver and tumor tissues of the mice were preserved for immunohistochemistry analysis.

Results: In vitro anticancer activity of TIPP showed significant inhibition on cell viability of both breast cancer and chronic myeloid leukemia. In vivo anticancer effect of TIPP in both types of cancer models further proved the potent anticancer nature of TIPP. Immunohistochemistry analysis assured that TIPP is a safe drug for normal organs such as the liver.

Conclusion: Our present study revealed that TIPP is a potent anticancer drug and an important treatment option for various diseases. Further work is needed to test the flexible and proficient activity of the novel peptide.

目标：作为全球死亡的共同原因和主要负担，及时的癌症管理至关重要。

背景：胸腺免疫抑制五肽（TIPP）是一种新颖的五肽，最初是从小牛胸腺免疫抑制提取物中获得的。此前，已证明 TIPP 通过阻断 MAP 激酶/NF-κB 信号通路抑制过敏小鼠的过敏和炎症反应。

目的：在本研究中，使用 MCF-7 和 K562 细胞系测试了 TIPP 对两种不同类型癌症的体外抗癌活性。

方法：设计乳腺癌和慢性粒细胞白血病的异种移植瘤模型。研究了 TIPP 对两种癌症类型的体内抗癌活性。保存小鼠的肝脏和肿瘤组织用于免疫组织化学分析。

结果： TIPP 的体外抗癌活性对乳腺癌和慢性粒细胞白血病的细胞活力均有显着抑制作用。TIPP在两种癌症模型中的体内抗癌作用进一步证明了TIPP的强效抗癌特性。免疫组织化学分析确保 TIPP 对肝脏等正常器官是一种安全的药物。

结论：我们目前的研究表明，TIPP 是一种有效的抗癌药物，是各种疾病的重要治疗选择。需要进一步的工作来测试新肽的灵活和熟练的活性。