Cell–cell communication plays a critical role in cell proliferation, differentiation, morphogenesis, functiogenesis, and tissue homoeostasis in multicellular organisms, while abnormal communication among cells may disrupt biological processes [1]. Intercellular communication is largely mediated by gap junctions (GJs), consisting of arrays of intercellular channels that enable cells to communicate by allowing ions and small molecules to directly transfer between neighboring cells [2]. Three families of integral membrane proteins forming GJ have been identified as innexins, connexins, and pannexins [2]. In vertebrates, six connexins (Cxs) oligomerized to connexons function as hemichannels and assemble...

中文翻译：

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慢性内质网应激的细胞间传递：代谢性疾病的新机制

细胞间通讯在多细胞生物的细胞增殖、分化、形态发生、功能发生和组织稳态中起着关键作用，而细胞间的异常通讯可能会破坏生物过程。1]。细胞间通讯主要由间隙连接 (GJ) 介导，间隙连接由一系列细胞间通道组成，通过允许离子和小分子在相邻细胞之间直接转移，使细胞能够进行通信。2]。形成 GJ 的三个完整膜蛋白家族已被鉴定为 innexins、connexins 和 pannexins。2]。在脊椎动物中，六个连接蛋白 (Cxs) 寡聚化为连接子作为半通道并组装...