Recently, ovarian cancer research has evolved considerably because of the emerging recognition that rather than a single disease, ovarian carcinomas comprise several different histotypes that vary by etiologic origin, risk factors, molecular profiles, therapeutic approaches and clinical outcome. Despite significant progress in our understanding of the etiologic heterogeneity of ovarian cancer, as well as important clinical advances, it remains the eighth most frequently diagnosed cancer in women worldwide and the most fatal gynecologic cancer. The International Agency for Research on Cancer and the United States National Cancer Institute jointly convened an expert panel on ovarian carcinoma to develop consensus research priorities based on evolving scientific discoveries. Expertise ranged from etiology, prevention, early detection, pathology, model systems, molecular characterization and treatment/clinical management. This report summarizes the current state of knowledge and highlights expert consensus on future directions to continue advancing etiologic, epidemiologic and prognostic research on ovarian carcinoma.

中文翻译：

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IARC/NCI 国际癌症研讨会联合系列报告：卵巢癌研究未来方向的专家共识。


最近，卵巢癌研究取得了长足的发展，因为人们逐渐认识到卵巢癌不是单一疾病，而是由几种不同的组织型组成，这些组织型因病因起源、危险因素、分子特征、治疗方法和临床结果而异。尽管我们对卵巢癌病因异质性的理解取得了重大进展，并且在临床上也取得了重要进展，但它仍然是全世界女性中第八大最常诊断的癌症，也是最致命的妇科癌症。国际癌症研究机构和美国国家癌症研究所联合召集了卵巢癌专家小组，根据不断发展的科学发现制定共识研究重点。专业知识涵盖病因学、预防、早期检测、病理学、模型系统、分子表征和治疗/临床管理。本报告总结了当前的知识状况，并强调了专家对继续推进卵巢癌病因学、流行病学和预后研究的未来方向的共识。