Hypertrophic scar is a dermal fibroproliferative disease characterized by increased collagen bundles [1]. A variety of factors participate in its formation, including inflammation, genetics, growth factors, and cytokines [2‒3,4,5]. Among the cytokines, tumor necrosis factor (TNF)-α secreted by peripheral blood mononuclear cells is lower in the hypertrophic scar group compared with the normal group [6]. However, the effect of TNF-α on fibroblasts and the underlying mechanism of TNF-α in hypertrophic scar has not been revealed.

中文翻译：

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TNF-α通过miR-141-3p抑制增生性瘢痕成纤维细胞的纤维化和迁移

增生性瘢痕是一种以胶原束增多为特征的皮肤纤维增生性疾病。1]。多种因素参与其形成，包括炎症、遗传、生长因子和细胞因子。2-3、4、5]。细胞因子中，增生性瘢痕组外周血单个核细胞分泌的肿瘤坏死因子（TNF）-α低于正常组[1]。6]。然而，TNF-α对成纤维细胞的影响以及TNF-α在增生性瘢痕中的潜在机制尚未揭示。