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Roles of Interferon Induced Protein with Tetratricopeptide Repeats (IFIT) Family in Cancer
Current Medicinal Chemistry ( IF 3.5 ) Pub Date : 2021-07-31 , DOI: 10.2174/0929867328666210617105209
Xing Fei Tan 1 , Qifan Chen 1 , San Hue Hua 1 , George Wai Yip 1
Affiliation  

The Interferon-induced protein with tetratricopeptide repeats (IFIT) family is an important component of the antiviral immune response. There are currently four known IFIT family members in humans, namely IFIT1, IFIT2, IFIT3 and IFIT5. Recent discoveries have brought attention to the significant roles of IFITs in cancer. This review summarises current knowledge on the biological roles of different IFIT proteins in various types of malignant neoplasm, and highlights the potential use of these molecules as cancer biomarkers and prognostic factors.



中文翻译:

具有四肽重复序列 (IFIT) 家族的干扰素诱导蛋白在癌症中的作用

具有四肽重复序列的干扰素诱导蛋白 (IFIT) 家族是抗病毒免疫反应的重要组成部分。目前人类已知的 IFIT 家族成员有四个,即 IFIT1、IFIT2、IFIT3 和 IFIT5。最近的发现引起了人们对 IFIT 在癌症中的重要作用的关注。本综述总结了目前关于不同 IFIT 蛋白在各种类型的恶性肿瘤中的生物学作用的知识,并强调了这些分子作为癌症生物标志物和预后因素的潜在用途。

更新日期:2021-08-16
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