Neurodegenerative diseases have emerged as one of the major age-associated diseases in recent years. Hence, the urge to understand the mechanism and to find targeted therapeutics becomes inevitable. Peptide-based compounds have emerged as one of the important tools for their therapy. However, due to a lack of tolerability, specificity, and proteolytic degradation, they have lost their applicability in the broader sense.

Thus, the search for suitable alternatives or peptidomimetics becomes an important criterion for neurotherapeutics. One of the versatile peptidomimetics is N-substituted glycines or peptoids, which retain many properties of peptides but successfully evade the drawbacks of peptides. Peptoids are manifested with greater cellular permeability, less immunogenicity, and their ability to be administered intra-nasally. These properties enhance their potential as neurotherapeutics with respect to their peptide counterparts. Recently, peptoids have been explored for neurotherapeutic applications as aggregation inhibitors, cell signaling pathways modulators, and agents for inhibiting inflammation via multiple mechanisms. Peptoids, due to their versatility and low production cost, are becoming popular among peptidomimetics as potential neurotherapeutic agents. In this review, the diverse applications of peptoids with respect to neurodegenerative disease have been explored.

近年来，神经退行性疾病已成为主要的与年龄相关的疾病之一。因此，了解机制和寻找靶向治疗的冲动变得不可避免。基于肽的化合物已成为其治疗的重要工具之一。然而，由于缺乏耐受性、特异性和蛋白水解降解，它们已经失去了更广泛意义上的适用性。

因此，寻找合适的替代物或肽模拟物成为神经治疗学的重要标准。一种通用的肽模拟物是 N 取代的甘氨酸或类肽，它保留了肽的许多特性，但成功地规避了肽的缺点。拟肽表现出更大的细胞渗透性、更低的免疫原性以及它们经鼻给药的能力。相对于它们的肽对应物，这些特性增强了它们作为神经治疗剂的潜力。最近，已经探索了类肽作为聚集抑制剂、细胞信号通路调节剂和通过多种机制抑制炎症的药物的神经治疗应用。Peptoids，由于其多功能性和低生产成本，作为潜在的神经治疗剂，肽模拟物正变得越来越流行。在这篇综述中，探索了类肽在神经退行性疾病方面的多种应用。