Dendritic cells (DCs) and monocytes are widely conserved immune cells in vertebrates that arise from hematopoietic stem cells via intermediate progenitors. The progenitors that strictly give rise to DCs or monocytes have been recently identified both in humans and in mice, thereby revealing their differentiation pathways. Advances in analysis technologies have further deepened our understanding of the development of DCs and monocytes from progenitor population-based to individual progenitor cell-based commitment. Since DC-committed progenitors, common DC progenitors (CDPs) and precursor conventional DCs (pre-cDCs) do not differentiate into monocytes, DCs are a distinct lineage from monocytes, although monocytes can acquire DC functions upon activation at tissues where they arrive.

中文翻译：

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致力于树突状细胞和单核细胞。

树突状细胞 (DC) 和单核细胞是脊椎动物中广泛保守的免疫细胞，它们是通过中间祖细胞从造血干细胞产生的。最近在人类和小鼠中都发现了严格产生 DC 或单核细胞的祖细胞，从而揭示了它们的分化途径。分析技术的进步进一步加深了我们对 DCs 和单核细胞从基于祖细胞群到基于个体祖细胞的承诺发展的理解。由于 DC 定向祖细胞、普通 DC 祖细胞 (CDP) 和前体常规 DC (pre-cDC) 不会分化成单核细胞，因此 DC 是与单核细胞不同的谱系，尽管单核细胞在它们到达的组织处激活后可以获得 DC 功能。