Biomedical research often enrolls people living with HIV (PLWH) receiving effective treatment to complete invasive procedures. This mixed methods study characterized determinants of willingness to undergo specific biomedical procedures among PLWH. In 2017, 61 participants (77% Black) from Miami completed a quantitative assessment examining willingness to participate. A subset of 19 participants completed an in-depth qualitative interview. Across all procedures, there was greater willingness to participate if asked by a primary care provider and if experimental results were shared. However, half of participants reported that they would experience undue influence (i.e., excessive persuasion) to participate from their primary care provider. In thematic analyses, altruism and personal benefit were identified as facilitators while medication changes, confidentiality, and perceived stigma were identified as barriers to participation in HIV biomedical research. Addressing participants’ expectations and mitigating potential undue influence from primary care providers could optimize the ethical conduct of HIV biomedical studies.

生物医学研究通常招募接受有效治疗的 HIV 感染者 (PLWH) 以完成侵入性手术。这项混合方法研究表征了 PLWH 愿意接受特定生物医学程序的决定因素。2017 年，来自迈阿密的 61 名参与者（77% 是黑人）完成了对参与意愿的定量评估。19 名参与者的子集完成了深入的定性访谈。在所有程序中，如果初级保健提供者提出要求并且如果共享实验结果，则参与的意愿会更高。然而，一半的参与者报告说，他们会受到来自初级保健提供者的不当影响（即过度说服）。在专题分析中，利他主义和个人利益被确定为药物改变时的促进因素，保密和被认为的耻辱被认为是参与 HIV 生物医学研究的障碍。满足参与者的期望并减轻初级保健提供者的潜在不当影响，可以优化 HIV 生物医学研究的道德行为。